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Keywords: tMCAO
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Journal Articles

Predicting experimental success: a retrospective case-control study using the rat intraluminal thread model of stroke

Open Access
In collection:
Rat as a Disease Model
Lisa Liebenstund, Mark Coburn, Christina Fitzner, Antje Willuweit, Karl-Josef Langen, Jingjin Liu, Michael Veldeman, Anke Höllig
Journal: Disease Models & Mechanisms
Dis Model Mech (2020) 13 (12): dmm044651.
https://doi.org/10.1242/dmm.044651
Published: 29 December 2020
... cerebral artery occlusion (tMCAO) experiments, including detailed intraoperative monitoring to elaborate predictors indicating experimental success (ischemia without occurrence of confounding pathologies). The tMCAO monitoring data (bilateral cerebral blood flow, CBF; heart rate, HR; and mean arterial...
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Includes: Supplementary data
Journal Articles

Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke

Open Access
In collection:
Rat as a Disease Model
Syed Suhail Andrabi, Mubashshir Ali, Heena Tabassum, Sabiha Parveen, Suhel Parvez
Journal: Disease Models & Mechanisms
Dis Model Mech (2019) 12 (8): dmm033860.
https://doi.org/10.1242/dmm.033860
Published: 29 August 2019
... neuroprotection through mitochondria. Considering this, we examined the possible mitochondrial role of pramipexole in promoting neuroprotection following an ischemic stroke of rat. Male Wistar rats underwent transient middle cerebral artery occlusion (tMCAO) and then received pramipexole (0.25 mg and 1 mg/kg body...
View articletitled, Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke
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Includes: Supplementary data