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Keywords: mdx
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Journal Articles
Dis Model Mech (2024) 17 (10): dmm050852.
Published: 9 October 2024
...Conner C. Earl; Areli J. Javier; Alyssa M. Richards; Larry W. Markham; Craig J. Goergen; Steven S. Welc ABSTRACT Cardiomyopathy is the leading cause of death in Duchenne muscular dystrophy (DMD); however, in the mdx mouse model of DMD, the cardiac phenotype differs from that seen in DMD-associated...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2014) 7 (1): 41–54.
Published: 1 January 2014
... that genetic increase of the levels of the bioactive sphingolipid sphingosine-1-phosphate (S1P) or delivery of 2-acetyl-5-tetrahydroxybutyl imidazole (THI), an S1P lyase inhibitor, suppresses dystrophic muscle degeneration. In the dystrophic mouse ( mdx ), upregulation of S1P by THI increases regeneration...
Includes: Supplementary data