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Keywords: iPSCs
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Journal Articles
Journal Articles
Dis Model Mech (2022) 15 (11): dmm049541.
Published: 28 November 2022
... of the compartmentalization process leads to esophageal atresia/tracheoesophageal fistula (EA/TEF). The cause of EA/TEF remains largely unknown. Therefore, to mimic the early development of the esophagus and trachea, we differentiated induced pluripotent stem cells (iPSCs) from EA/TEF patients, and iPSCs and embryonic stem...
Includes: Supplementary data
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Stem Cells
Dis Model Mech (2020) 13 (1): dmm042317.
Published: 17 January 2020
...Viola Volpato; Caleb Webber ABSTRACT Induced pluripotent stem cell (iPSC) technologies have provided in vitro models of inaccessible human cell types, yielding new insights into disease mechanisms especially for neurological disorders. However, without due consideration, the thousands of new human...
Journal Articles
Dis Model Mech (2020) 13 (1): dmm042317.
Published: 17 January 2020
...Viola Volpato; Caleb Webber ABSTRACT Induced pluripotent stem cell (iPSC) technologies have provided in vitro models of inaccessible human cell types, yielding new insights into disease mechanisms especially for neurological disorders. However, without due consideration, the thousands of new human...
Journal Articles
Dis Model Mech (2019) 12 (8): dmm039552.
Published: 16 August 2019
... genetic cause of ALS, a hexanucleotide repeat expansion in the C9ORF72 gene, has yet to be fully characterized in the context of skeletal muscle. In this study, we used the protocol previously developed in our lab to differentiate skeletal myocytes from induced pluripotent stem cells (iPSCs) of C9ORF72...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (8): dmm039552.
Published: 16 August 2019
... genetic cause of ALS, a hexanucleotide repeat expansion in the C9ORF72 gene, has yet to be fully characterized in the context of skeletal muscle. In this study, we used the protocol previously developed in our lab to differentiate skeletal myocytes from induced pluripotent stem cells (iPSCs) of C9ORF72...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2017) 10 (5): 537–549.
Published: 1 May 2017
... of the etiology and pathology of this neurodegenerative disease. C. elegans Fruit fly Motor neuron Neurodegeneration Zebrafish iPSCs Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that primarily affects the motor neurons (MNs) in the motor cortex, brainstem and spinal...
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Dis Model Mech (2016) 9 (7): 719–735.
Published: 1 July 2016
..., the inhibition of these factors improves reprogramming efficiency ( Banito and Gil, 2010 ; Hong et al., 2009 ). Metabolic studies also indicate that inhibition of mammalian target of rapamycin (mTOR) notably improves the efficiency of iPSC generation ( Chen et al., 2011 ), identifying mTOR as an important...
Journal Articles
Dis Model Mech (2016) 9 (1): 39–49.
Published: 1 January 2016
... type 1 patient-specific induced pluripotent stem cells (iPSCs) and differentiating these cells into spinal motor neurons. The initial specification of spinal motor neurons was not affected, but these SMA spinal motor neurons specifically degenerated following long-term culture. Moreover, at an early...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2016) 9 (1): 39–49.
Published: 1 January 2016
... type 1 patient-specific induced pluripotent stem cells (iPSCs) and differentiating these cells into spinal motor neurons. The initial specification of spinal motor neurons was not affected, but these SMA spinal motor neurons specifically degenerated following long-term culture. Moreover, at an early...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (7): 755–766.
Published: 1 July 2015
...Jessica Lenzi; Riccardo De Santis; Valeria de Turris; Mariangela Morlando; Pietro Laneve; Andrea Calvo; Virginia Caliendo; Adriano Chiò; Alessandro Rosa; Irene Bozzoni ABSTRACT Patient-derived induced pluripotent stem cells (iPSCs) provide an opportunity to study human diseases mainly in those...
Includes: Supplementary data