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1-7 of 7
Keywords: iPSC
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Journal Articles
In collection:
Advanced in vitro models
Jinlun Bai, David S. Koos, Kayla Stepanian, Zachary Fouladian, Dominic W. H. Shayler, Jennifer G. Aparicio, Scott E. Fraser, Rex A. Moats, David Cobrinik
Journal:
Disease Models & Mechanisms
Dis Model Mech (2023) 16 (11): dmm050193.
Published: 21 November 2023
... (iPSCs) by inserting enhanced green fluorescent protein (EGFP) coding sequences and a 2A self-cleaving peptide at the N-terminus of guanine nucleotide-binding protein subunit alpha transducin 2 (GNAT2). In retinal organoids generated from these iPSCs, the GNAT2-EGFP alleles robustly and exclusively...
Includes: Supplementary data
Journal Articles
An induced pluripotent stem cell-based model identifies molecular targets of vincristine neurotoxicity
Open AccessIn collection:
Advanced in vitro models
Neng-Wei Tsai, Cheng-Chen Lin, Ti-Yen Yeh, Yu-An Chiu, Hsin-Hui Chiu, Hsiang-Po Huang, Sung-Tsang Hsieh
Journal:
Disease Models & Mechanisms
Dis Model Mech (2022) 15 (12): dmm049471.
Published: 15 December 2022
...Neng-Wei Tsai; Cheng-Chen Lin; Ti-Yen Yeh; Yu-An Chiu; Hsin-Hui Chiu; Hsiang-Po Huang; Sung-Tsang Hsieh ABSTRACT To model peripheral nerve degeneration and investigate molecular mechanisms of neurodegeneration, we established a cell system of induced pluripotent stem cell (iPSC)-derived sensory...
Includes: Supplementary data
Journal Articles
Giusj Monia Pugliese, Federico Salaris, Valentina Palermo, Veronica Marabitti, Nicolò Morina, Alessandro Rosa, Annapaola Franchitto, Pietro Pichierri
Journal:
Disease Models & Mechanisms
Dis Model Mech (2019) 12 (10): dmm039487.
Published: 17 October 2019
... pluripotent stem cells (iPSCs) to mimic conditions associated with the severe form the disease. Using multiple cellular endpoints, we characterized this model for the presence of phenotypes linked to the replication caretaker role of SMARCAL1. Our data show that conditional knockdown of SMARCAL1 in human...
Includes: Supplementary data
Journal Articles
mTOR hyperactivity mediates lysosomal dysfunction in Gaucher's disease iPSC-neuronal cells
Open AccessRobert A. Brown, Antanina Voit, Manasa P. Srikanth, Julia A. Thayer, Tami J. Kingsbury, Marlene A. Jacobson, Marta M. Lipinski, Ricardo A. Feldman, Ola Awad
Journal:
Disease Models & Mechanisms
Dis Model Mech (2019) 12 (10): dmm038596.
Published: 16 October 2019
... pluripotent stem cell (iPSC) model of GD, we previously demonstrated that lysosomal alterations in GD neurons are linked to dysfunction of the transcription factor EB (TFEB). TFEB controls the coordinated expression of autophagy and lysosomal genes and is negatively regulated by the mammalian target...
Includes: Supplementary data
Journal Articles
In collection:
Stem Cells
Mostafa Kiamehr, Leena E. Viiri, Terhi Vihervaara, Kaisa M. Koistinen, Mika Hilvo, Kim Ekroos, Reijo Käkelä, Katriina Aalto-Setälä
Journal:
Disease Models & Mechanisms
Dis Model Mech (2017) 10 (9): 1141–1153.
Published: 1 September 2017
...Mostafa Kiamehr; Leena E. Viiri; Terhi Vihervaara; Kaisa M. Koistinen; Mika Hilvo; Kim Ekroos; Reijo Käkelä; Katriina Aalto-Setälä ABSTRACT Hepatocyte-like cells (HLCs) differentiated from human induced pluripotent stem cells (iPSCs) offer an alternative model to primary human hepatocytes to study...
Includes: Supplementary data
Journal Articles
Wojciech J. Szlachcic, Pawel M. Switonski, Wlodzimierz J. Krzyzosiak, Marek Figlerowicz, Maciej Figiel
Journal:
Disease Models & Mechanisms
Dis Model Mech (2015) 8 (9): 1047–1057.
Published: 1 September 2015
... cells, such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Therefore, we examined putative signaling pathways and processes involved in HD pathogenesis in pluripotent cells. We tested naïve mouse HD YAC128 iPSCs and two types of human HD iPSC that were generated from HD...
Includes: Supplementary data
Journal Articles
Journal:
Disease Models & Mechanisms
Dis Model Mech (2015) 8 (5): 421–427.
Published: 1 May 2015
... millions of people worldwide. AMD RPE Cell-culture models hESC iPSC Stem-cell therapy AMD – age-related macular degeneration – is a leading cause of blindness for millions of people over the age of 60. The disease is associated not only with visual impairment, but also with high rates...
