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Keywords: iDISCO
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Journal Articles

Quantitative whole-brain 3D imaging of tyrosine hydroxylase-labeled neuron architecture in the mouse MPTP model of Parkinson's disease

Open Access
In collection:
Neurodegenerative Disorders
Urmas Roostalu, Casper B. G. Salinas, Ditte D. Thorbek, Jacob L. Skytte, Katrine Fabricius, Pernille Barkholt, Linu M. John, Vanessa Isabell Jurtz, Lotte Bjerre Knudsen, Jacob Jelsing, Niels Vrang, Henrik H. Hansen, Jacob Hecksher-Sørensen
Journal: Disease Models & Mechanisms
Dis Model Mech (2019) 12 (11): dmm042200.
https://doi.org/10.1242/dmm.042200
Published: 22 November 2019
... in central dopaminergic pathways, we used iDISCO immunolabeling, light-sheet fluorescence microscopy (LSFM) and deep-learning computational methods for whole-brain three-dimensional visualization and automated quantitation of tyrosine hydroxylase (TH)-positive neurons in the adult mouse brain. Mice...
View articletitled, Quantitative whole-brain 3D imaging of tyrosine hydroxylase-labeled neuron architecture in the mouse MPTP model of Parkinson's disease
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Includes: Supplementary data