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Keywords: Zebrafish
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Journal Articles
Dis Model Mech dmm.048439.
Published: 30 April 2021
... microtubules. Zebrafish ccdc103 / schmalhans ( smh ) mutants have macrophages and neutrophils with reduced proliferation, abnormally-rounded cell morphology, and an inability to migrate efficiently to the site of sterile wounds, all of which are consistent with a loss of cytoplasmic microtubule stability...
Journal Articles
Dis Model Mech (2021) 14 (4): dmm047761.
Published: 26 April 2021
... disease spinal muscular atrophy (SMA). Compounds that can counteract synaptic destabilisation are rare. Here, we describe an automated screening paradigm in zebrafish for small-molecule compounds that stabilize the neuromuscular synapse in vivo . We make use of a mutant for the axonal C-type lectin...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (11): dmm043885.
Published: 27 November 2020
...Alaa Koleilat; Joseph A. Dugdale; Trace A. Christenson; Jeffrey L. Bellah; Aaron M. Lambert; Mark A. Masino; Stephen C. Ekker; Lisa A. Schimmenti ABSTRACT The mariner ( myo7aa −/− ) mutant is a zebrafish model for Usher syndrome type 1 (USH1). To further characterize hair cell synaptic elements in...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (9): dmm045971.
Published: 24 September 2020
...Jelmer Hoeksma; Gerard C. M. van der Zon; Peter ten Dijke; Jeroen den Hertog ABSTRACT Zebrafish models are well-established tools for investigating the underlying mechanisms of diseases. Here, we identified cercosporamide, a metabolite from the fungus Ascochyta aquiliqiae , as a potent bone...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (8): dmm045716.
Published: 23 August 2020
... preclinical evaluation of novel tuberculosis vaccine candidates is also hampered by the lack of an appropriate animal model that could accurately predict the protective effect of vaccines in humans. Here, we review the role of zebrafish ( Danio rerio ) and other fish models in the development of novel...
Journal Articles
Dis Model Mech (2020) 13 (7): dmm043091.
Published: 20 July 2020
... immune responses observed in mouse versus human cells. Here, we developed a zebrafish infection model to study the innate immune response to Toxoplasma in vivo . By infecting the zebrafish hindbrain ventricle, and using high-resolution microscopy techniques coupled with computer vision-driven automated...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (6): dmm042556.
Published: 26 June 2020
... fluorescent reporter in a dose-dependent manner. Furthermore, cytokine misexpression is enabled only in tissue domains that can be defined by Cre recombinase expression. We have validated this system in zebrafish using an insulin : cre line. In doubly transgenic fish, quantitative real-time polymerase chain...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (6): dmm042549.
Published: 24 June 2020
... genetic control of bone development and provide new zebrafish models for human disorders of the cholesterol biosynthesis pathway. We identified a novel mutation, referred to as kol nu7 , based on the reduced body length and small head size of adult homozygote fish ( Fig. 1 A). The kol nu7 phenotype...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (5): dmm044131.
Published: 27 May 2020
... regenerate after injury. In stark contrast, the regeneration of a completely transected spinal cord and accompanying reversal of paralysis in adult zebrafish is arguably one of the most spectacular biological phenomena in nature. Here, we review reports from the last decade that dissect the mechanisms of...
Journal Articles
Dis Model Mech (2020) 13 (4): dmm043877.
Published: 29 April 2020
... phenotypes have been generated, the underlying molecular mechanisms remain largely elusive. Over the past decades, the zebrafish has emerged as a powerful vertebrate model that has led to fundamental discoveries in developmental neurobiology and behavioral genetics. Here, we review the attributes that make...
Journal Articles
Dis Model Mech (2020) 13 (4): dmm043844.
Published: 01 April 2020
... toxicology research to utilize diverse model systems, including zebrafish, and perform more mechanistic studies of cellular responses to chemical exposures to shift the perception of toxicology as an applied science to that of a basic science. This more-inclusive perspective will enrich the field and should...
Journal Articles
Dis Model Mech (2020) 13 (3): dmm042689.
Published: 30 March 2020
... diseases. Owing to their amenability to rapid genetic intervention and the large number of conserved genetic and physiological features, small teleosts – such as zebrafish, medaka and killifish – have become indispensable for skeletal muscle genomic studies. The goal of this Review is to summarize evidence...
Journal Articles
Dis Model Mech (2020) 13 (1): dmm041426.
Published: 28 January 2020
... to the nucleus to activate transcriptional targets. Here, we describe the establishment and validation of zebrafish reporter lines for ATF6 activity. These transgenic lines are based on a defined and multimerized ATF6 consensus site, which drives either eGFP or destabilized eGFP, enabling dynamic...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (12): dmm040170.
Published: 20 December 2019
... patients have a severely shortened life expectancy and without treatment die, generally from sepsis soon after birth. The only available therapeutic option for RD is hematopoietic stem cell transplantation (HSCT). To gain insight into the pathophysiology of RD, we previously created zebrafish models for...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (9): dmm037630.
Published: 03 September 2019
... inflammation. Because of the cellular complexity of fracture repair, as well as genetic and environmental influences, there is a need for models that permit visualisation of the fracture repair process under clinically relevant conditions. To characterise the process of fracture repair in zebrafish, we...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (5): dmm037887.
Published: 30 May 2019
... order to improve glucocorticoid therapies, more research is required into the mechanisms of glucocorticoid action. In the present study, we have used a zebrafish model for inflammation to study glucocorticoid effects on the innate immune response. In zebrafish larvae, the migration of neutrophils...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (3): dmm037903.
Published: 28 March 2019
... molecule in mediating benzene-induced hematotoxicity and carcinogenicity. However, its pathogenic role remains largely unknown due to a lack of suitable vertebrate whole-organism models. Here, we present an in vivo study to reveal the effect of BQ exposure on hematotoxicity in zebrafish. From embryonic...
Journal Articles
Dis Model Mech (2019) 12 (3): dmm039370.
Published: 07 March 2019
...E. Elizabeth Patton; David M. Tobin ABSTRACT Five years after the launch of the Disease Models & Mechanisms (DMM) Special Issue on zebrafish as a disease model, the field has progressed significantly. Zebrafish have been used to precisely model human genetic variants, to unpick the mechanisms...
Journal Articles
Dis Model Mech (2019) 12 (2): dmm038240.
Published: 27 February 2019
...Qiqi Yang; Chuan Yan; Xu Wang; Zhiyuan Gong ABSTRACT Cancer cachexia affects up to 80% of patients with advanced solid cancer and leads to excessive muscle wasting. Here, using an inducible zebrafish hepatocellular carcinoma (HCC) model driven by oncogenic kras G12V , we observed a progressive...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (1): dmm036004.
Published: 23 January 2019
... islet inflammation in zebrafish, a vertebrate that allows for non-invasive imaging of β-cells and in vivo drug discovery. Live imaging of immune cells and β-cells in our model revealed dynamic migration, increased visitation and prolonged macrophage retention in the islet, together with robust...
Includes: Supplementary data