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Keywords: Zebrafish
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Journal Articles
Dis Model Mech dmm.050438.
Published: 15 May 2024
... in understanding the pathogenesis of DN, more efficient models are required to develop new therapeutics. Here, we created a DN model in zebrafish by crossing diabetic Tg(acta1:dnIGF1R-EGFP) and proteinuria-tracing Tg(l-fabp::VDBP-GFP) lines, named zMIR/VDBP. Overfed adult zMIR/VDBP fish developed severe...
Journal Articles
Dis Model Mech (2024) 17 (3): dmm050581.
Published: 5 March 2024
... to those of telomerase mutants. Here, we discuss the impact of this phenomenon on human pathologies associated with telomere length, provide a brief overview of telomere biology across species and propose specific measures for working with telomerase-deficient zebrafish. * Author for correspondence...
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Dis Model Mech (2023) 16 (9): dmm050092.
Published: 5 September 2023
.... The underlying mechanism contributing to disease onset in response to specific triggers remains unclear. To address these challenges, we created a zebrafish model of Tango2 deficiency. Here, we demonstrate that the loss of Tango2 in zebrafish results in growth defects, early lethality and increased...
Includes: Supplementary data
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Dis Model Mech (2023) 16 (6): dmm049908.
Published: 10 May 2023
... Health Organisation (WHO) to highlight Shigella as a priority pathogen requiring urgent attention. Several infection models have been useful to explore the Shigella infection process; yet, we still lack information regarding events taking place in vivo . Here, using a Shigella -zebrafish infection model...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2023) 16 (6): dmm049954.
Published: 10 May 2023
... to an earlier age of PD onset. Despite both converging on the ceramide pathway, how the combined deficiencies of both enzymes might interact to modulate PD has yet to be explored. Therefore, we created a double-knockout (DKO) zebrafish line for both gba1 (or gba ) and smpd1 to test for an interaction in vivo...
Includes: Supplementary data
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Dis Model Mech (2023) 16 (4): dmm049911.
Published: 3 April 2023
... stratified adult skin are unknown. Here, we established zebrafish scales as a tractable model to study axon degeneration in the adult epidermis. Using this system, we demonstrated that skin-resident immune cells known as Langerhans cells engulf the majority of axon debris. In contrast to immature skin, adult...
Includes: Supplementary data
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Dis Model Mech (2023) 16 (3): dmm049841.
Published: 13 March 2023
... mutations of the PIK3CD gene that encodes the PI3 kinase delta (PI3Kδ) catalytic subunit. Despite the importance of innate immunity defects in bronchiectasis, there has been limited investigation of neutrophils or macrophages in APDS1 patients or mouse models. Zebrafish embryos provide an ideal system...
Includes: Supplementary data
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Dis Model Mech (2023) 16 (2): dmm049793.
Published: 8 February 2023
... zebrafish to explore the growth dynamics of oncogenic clones during development. Here, in a subset of clones, we observed a local increase in proportion of the fin skeleton closely resembling overgrowth phenotypes in patients. We unravel the cellular and developmental mechanisms of these overgrowths...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2023) 16 (2): dmm049715.
Published: 30 January 2023
... the phenotype seen in motheaten mice that lack functional SHP1. To investigate the function of Shp1 in developing zebrafish embryos, we generated a ptpn6 knockout zebrafish line lacking functional Shp1. Shp1 knockout caused severe inflammation and lethality around 17 days post fertilization (dpf). During early...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2023) 16 (1): dmm049671.
Published: 20 January 2023
..., we generated a zebrafish system that can be used as a platform for studying these factors. We studied how germline overexpression of Agrp along with a high-fat diet affects melanomas dependent on BRAF V600E and loss of p53. This revealed an increase in tumor incidence and area in male, but not female...
Includes: Supplementary data
Journal Articles