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Keywords: Xenograft
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Journal Articles
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Cancer , Drug Discovery
Dis Model Mech (2022) 15 (9): dmm049457.
Published: 29 August 2022
... models in basic biology and efficacy testing has been cited as a potential cause of failure in clinical trials. We developed and characterized five diverse RAG1 null mouse strains as models that allow xenografts to grow. In these strains, we characterized the growth of breast cancer, leukemia and glioma...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (10): dmm046904.
Published: 28 October 2020
... models, and an array of transgenic and xenograft in vivo models, with particular attention to newly developed systems and how they are being used to deepen our understanding of FSHD pathology and to test the efficacy of drug candidates. A second transgenic zebrafish model developed by Pakula et al...
Journal Articles
In collection:
Cancer
Dis Model Mech (2019) 12 (9): dmm040386.
Published: 6 September 2019
... ( Singh et al., 2004 ). These findings support the cancer-stem-cell model for GBM, with subsets of tumour cells displaying NSC markers and these being more aggressive than their more differentiated progeny. Recent studies, using in vivo genetic-lineage tracing in xenografts, lend further support...
Journal Articles
Journal Articles
Journal Articles
Journal Articles
In collection:
Cancer
Dis Model Mech (2016) 9 (12): 1435–1444.
Published: 1 December 2016
...) for heterotypic in vivo modeling that recapitulates the heterogeneous biology and behavior of this disease. Both cell lines demonstrated stability of the transcriptome when grown as orthotopic xenografts in athymic nude mice. Consistent with the behavior of the original tumors, OS-2 xenografts grew more rapidly...
Includes: Supplementary data
Journal Articles
Journal Articles
Dis Model Mech (2015) 8 (10): 1247–1254.
Published: 1 October 2015
... or high expression of Myc oncoproteins. In a previous in vitro study, we found that the glycolytic inhibitor 2-deoxyglucose (2DG) could suppress the growth of neuroblastoma cells, particularly in those with MYCN amplification. In this study, we established a mouse model of neuroblastoma xenografts with SK...
Includes: Supplementary data