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1-3 of 3
Keywords: Vangl2
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Journal Articles
Beatriz Fernández-Santos, Marta Reyes-Corral, José Manuel Caro-Vega, Miguel Lao-Pérez, Claudia Vallejo-Grijalba, Cristina Mesa-Cruz, Francisco J. Morón, Patricia Ybot-González
Journal:
Disease Models & Mechanisms
Dis Model Mech (2023) 16 (8): dmm050175.
Published: 29 August 2023
... in animal models. Loop-tail ( Lp ) mice carry a mutation in the Vangl2 gene, a member of the Wnt-planar cell polarity pathway. In Vangl2 +/Lp embryos, the mutation induces a failure in the completion of caudal neural tube closure, but only a small percentage of embryos develop open spina bifida. Here, we...
Includes: Supplementary data
Journal Articles
Gabriel L. Galea, Oleksandr Nychyk, Matteo A. Mole, Dale Moulding, Dawn Savery, Evanthia Nikolopoulou, Deborah J. Henderson, Nicholas D. E. Greene, Andrew J. Copp
Journal:
Disease Models & Mechanisms
Dis Model Mech (2018) 11 (3): dmm032219.
Published: 21 March 2018
...Gabriel L. Galea; Oleksandr Nychyk; Matteo A. Mole; Dale Moulding; Dawn Savery; Evanthia Nikolopoulou; Deborah J. Henderson; Nicholas D. E. Greene; Andrew J. Copp ABSTRACT Human mutations in the planar cell polarity component VANGL2 are associated with the neural tube defect spina bifida...
Includes: Supplementary data
Journal Articles
Thanushiyan Poobalasingam, Laura L. Yates, Simone A. Walker, Miguel Pereira, Nina Y. Gross, Akmol Ali, Maria Kolatsi-Joannou, Marjo-Riitta Jarvelin, Juha Pekkanen, Eugenia Papakrivopoulou, David A. Long, Mark Griffiths, Darcy Wagner, Melanie Königshoff, Matthew Hind, Cosetta Minelli, Clare M. Lloyd, Charlotte H. Dean
Journal:
Disease Models & Mechanisms
Dis Model Mech (2017) 10 (4): 409–423.
Published: 1 April 2017
... of many PCP mouse mutant lines. Here, we investigate heterozygous Looptail ( Lp ) mice, in which a single copy of the core PCP gene, Vangl2 , is disrupted. We show that these mice are viable but display severe airspace enlargement and impaired adult lung function. Underlying these defects, we find...
Includes: Supplementary data