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Keywords: Unfolded protein response (UPR)
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Journal Articles

Muscle-specific lack of Gfpt1 triggers ER stress to alleviate misfolded protein accumulation

In collection:
Neuromuscular Disease , Rare Disease Translational Research
Ruchen Zhang, Paniz Farshadyeganeh, Bisei Ohkawara, Kazuki Nakajima, Jun-ichi Takeda, Mikako Ito, Shaochuan Zhang, Yuki Miyasaka, Tamio Ohno, Madoka Mori-Yoshimura, Akio Masuda, Kinji Ohno
Journal: Disease Models & Mechanisms
Dis Model Mech (2024) 17 (8): dmm050768.
https://doi.org/10.1242/dmm.050768
Published: 25 July 2024
... muscles. In Gfpt1 -KI mice, (1) UDP-HexNAc, CMP-NeuAc and protein O -GlcNAcylation were reduced in skeletal muscles; (2) aged Gfpt1 -KI mice showed poor exercise performance and abnormal neuromuscular junction structures; and (3) markers of the unfolded protein response (UPR) were elevated in skeletal...
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Includes: Supplementary data