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Keywords: Ulcerative colitis
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Journal Articles

Head-to-head study of oxelumab and adalimumab in a mouse model of ulcerative colitis based on NOD/Scid IL2Rγ null mice reconstituted with human peripheral blood mononuclear cells

In collection:
Drug Discovery
Henrika Jodeleit, Paula Winkelmann, Janina Caesar, Sebastian Sterz, Lesca M. Holdt, Florian Beigel, Johannes Stallhofer, Simone Breiteneicher, Eckart Bartnik, Thomas Leeuw, Matthias Siebeck, Roswitha Gropp
Journal: Disease Models & Mechanisms
Dis Model Mech (2021) 14 (1): dmm046995.
https://doi.org/10.1242/dmm.046995
Published: 21 January 2021
... and testing in a humanized mouse model of ulcerative colitis (UC) might lead to patient stratification for treatment with oxelumab. First, immunological profiles of UC patients and non-UC donors were analyzed for CD4 + T cells expressing OX40 (CD134; also known as TNFRSF4) and CD14 + monocytes expressing...
View article titled, Head-to-head study of oxelumab and adalimumab in a mouse model of <span class="search-highlight">ulcerative</span> <span class="search-highlight">colitis</span> based on NOD&#x2F;Scid IL2Rγ null mice reconstituted with human peripheral blood mononuclear cells
Open the PDF for Head-to-head study of oxelumab and adalimumab in a mouse model of <span class="search-highlight">ulcerative</span> <span class="search-highlight">colitis</span> based on NOD/Scid IL2Rγ null mice reconstituted with human peripheral blood mononuclear cells in another window
Includes: Supplementary data
Journal Articles

Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease

In collection:
Advanced in vitro models , Drug Discovery
Katie Lloyd, Stamatia Papoutsopoulou, Emily Smith, Philip Stegmaier, Francois Bergey, Lorna Morris, Madeleine Kittner, Hazel England, Dave Spiller, Mike H. R. White, Carrie A. Duckworth, Barry J. Campbell, Vladimir Poroikov, Vitor A. P. Martins dos Santos, Alexander Kel, Werner Muller, D. Mark Pritchard, Chris Probert, Michael D. Burkitt, The SysmedIBD Consortium
Journal: Disease Models & Mechanisms
Dis Model Mech (2020) 13 (11): dmm044040.
https://doi.org/10.1242/dmm.044040
Published: 27 November 2020
... Macrolide Ulcerative colitis Crohn's disease Seventh Framework Programme 10.13039/100011102 305564 Inflammatory bowel diseases (IBDs) affect 0.5-1.0% of people in the Western world and cause substantial morbidity and cost to society ( Feagan et al., 2014 ; van Deen et al., 2014...
View article titled, Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease
Open the PDF for Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease in another window
Includes: Supplementary data
Journal Articles

Targeting ulcerative colitis by suppressing glucose uptake with ritonavir

In collection:
Metabolic Disorders
Henrika Jodeleit, Omar Al-Amodi, Janina Caesar, Christina Villarroel Aguilera, Lesca Holdt, Roswitha Gropp, Florian Beigel, Matthias Siebeck
Journal: Disease Models & Mechanisms
Dis Model Mech (2018) 11 (11): dmm036210.
https://doi.org/10.1242/dmm.036210
Published: 21 November 2018
... , a mouse model was used that is based on immunocompromised NOD-scid IL-2Rγ null mice reconstituted with PBMCs from patients with ulcerative colitis (UC). Inflammation had a significant effect on amino acid (AA) levels (Glu P =1E-07, Asp P =1E-04). Principal component analysis (PCA) discriminated between...
View article titled, Targeting <span class="search-highlight">ulcerative</span> <span class="search-highlight">colitis</span> by suppressing glucose uptake with ritonavir
Open the PDF for Targeting <span class="search-highlight">ulcerative</span> <span class="search-highlight">colitis</span> by suppressing glucose uptake with ritonavir in another window
Includes: Supplementary data
Journal Articles

A mouse model for ulcerative colitis based on NOD- scid IL2R γ null mice reconstituted with peripheral blood mononuclear cells from affected individuals

Pia Palamides, Henrika Jodeleit, Michael Föhlinger, Florian Beigel, Nadja Herbach, Thomas Mueller, Eckhard Wolf, Matthias Siebeck, Roswitha Gropp
Journal: Disease Models & Mechanisms
Dis Model Mech (2016) 9 (9): 985–997.
https://doi.org/10.1242/dmm.025452
Published: 1 September 2016
...Pia Palamides; Henrika Jodeleit; Michael Föhlinger; Florian Beigel; Nadja Herbach; Thomas Mueller; Eckhard Wolf; Matthias Siebeck; Roswitha Gropp ABSTRACT Animal models reflective of ulcerative colitis (UC) remain a major challenge, and yet are crucial to understand mechanisms underlying the onset...
View article titled, A mouse model for <span class="search-highlight">ulcerative</span> <span class="search-highlight">colitis</span> based on NOD- scid IL2R γ null mice reconstituted with peripheral blood mononuclear cells from affected individuals
Open the PDF for A mouse model for <span class="search-highlight">ulcerative</span> <span class="search-highlight">colitis</span> based on NOD- scid IL2R γ null mice reconstituted with peripheral blood mononuclear cells from affected individuals in another window
Includes: Supplementary data