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Keywords: Tumor suppressor
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Journal Articles

RAS and beyond: the many faces of the neurofibromatosis type 1 protein

In collection:
The RAS Pathway
Corina Anastasaki, Paola Orozco, David H. Gutmann
Journal: Disease Models & Mechanisms
Dis Model Mech (2022) 15 (2): dmm049362.
https://doi.org/10.1242/dmm.049362
Published: 21 February 2022
... to define the importance of RAS regulation in health and disease. Emerging research has also unveiled the role of non-canonical RAS and RAS-independent signaling in this RASopathy. Neurofibromin RAS Cyclic AMP Tumor suppressor National Cancer Institute http://dx.doi.org/10.13039/100000054...
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Journal Articles

Enhancer of Polycomb and the Tip60 complex repress hematological tumor initiation by negatively regulating JAK/STAT pathway activity

In collection:
Cancer , Drosophila as a Disease Model
Alessandro A. Bailetti, Lenny J. Negrón-Piñeiro, Vishal Dhruva, Sneh Harsh, Sean Lu, Aisha Bosula, Erika A. Bach
Journal: Disease Models & Mechanisms
Dis Model Mech (2019) 12 (5): dmm038679.
https://doi.org/10.1242/dmm.038679
Published: 30 May 2019
.../STAT pathway by E(Pc) is dependent on substrates other than histones. Indeed, E(Pc) depletion significantly increased expression of Hop protein in myeloid cells. This study indicates that E(Pc) works as a tumor suppressor by attenuating Hop protein expression and ultimately JAK/STAT signaling. Since...
View articletitled, Enhancer of Polycomb and the Tip60 complex repress hematological tumor initiation by negatively regulating JAK/STAT pathway activity
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Includes: Supplementary data