..., cytokines were critical molecules to mediate immune response in the tumor microenvironment ( Lan et al., 2021 ). We hypothesized that adipokines secreted in response to an HFD are distributed to lung cancer tissue through the circulation and promote tumor progression. To connect HFD-induced signal networks...

...Libuše Janská; Libi Anandi; Nell C. Kirchberger; Zoran S. Marinkovic; Logan T. Schachtner; Gizem Guzelsoy; Carlos Carmona-Fontaine ABSTRACT There is an urgent need for accurate, scalable and cost-efficient models of the tumor microenvironment. Here, we detail how to fabricate and use the metabolic...

.... Here, we discuss how the metabolic tumor microenvironment modulates the phenotypes of the immune cells that infiltrate tumors, with an emphasis on tumor-associated macrophages. These cells constitute a diverse population that has pro-tumoral and anti-inflammatory properties, and are likened to anti...

... microenvironment, such as the biochemical composition, cellular population, extracellular matrix, and tissue (fluid) mechanics, have been indicated to play a pivotal role in the onset of metastasis. Dissecting the role of these cues from the tumor microenvironment in a controlled manner is challenging...

... mechanism of metastatic progression. Currently available in vitro models cannot replicate the three-dimensionality and heterogeneity of the tumor microenvironment sufficiently to recapitulate many of the known characteristics of tumors in vivo . Our understanding of metastatic progression would thus...