...Eva Habjan; Vien Q. T. Ho; James Gallant; Gunny van Stempvoort; Kin Ki Jim; Coen Kuijl; Daan P. Geerke; Wilbert Bitter; Alexander Speer ABSTRACT Finding new anti-tuberculosis compounds with convincing in vivo activity is an ongoing global challenge to fight the emergence of multidrug-resistant...

...Kamlesh Bhatt; Madhuri Bhagavathula; Sheetal Verma; Graham S. Timmins; Vojo P. Deretic; Jerrold J. Ellner; Padmini Salgame ABSTRACT Tuberculosis (TB) treatment regimens are lengthy, causing non-adherence to treatment. Inadequate treatment can lead to relapse and the development of drug resistance...

.... The tuberculosis (TB) research community has openly admitted to a vacuum of knowledge about neonatal and infant immune responses to Mycobacterium tuberculosis (Mtb) infection, especially in the functional and phenotypic attributes of memory T cell responses elicited by the only available vaccine for TB...

...Henna Myllymäki; Mirja Niskanen; Hanna Luukinen; Mataleena Parikka; Mika Rämet ABSTRACT Roughly one third of the human population carries a latent Mycobacterium tuberculosis infection, with a 5-10% lifetime risk of reactivation to active tuberculosis and further spreading the disease...

...Hanna Luukinen; Milka Marjut Hammarén; Leena-Maija Vanha-aho; Aleksandra Svorjova; Laura Kantanen; Sampsa Järvinen; Bruno Vincent Luukinen; Eric Dufour; Mika Rämet; Vesa Pekka Hytönen; Mataleena Parikka ABSTRACT Mycobacterium tuberculosis remains one of the most problematic infectious agents, owing...

...Elizabeth W. Tucker; Supriya Pokkali; Zhi Zhang; Vincent P. DeMarco; Mariah Klunk; Elizabeth S. Smith; Alvaro A. Ordonez; Marie-France Penet; Zaver Bhujwalla; Sanjay K. Jain; Sujatha Kannan ABSTRACT Central nervous system (CNS) tuberculosis (TB) is the most severe form of extra-pulmonary TB...

...Alvaro A. Ordonez; Rokeya Tasneen; Supriya Pokkali; Ziyue Xu; Paul J. Converse; Mariah H. Klunk; Daniel J. Mollura; Eric L. Nuermberger; Sanjay K. Jain ABSTRACT Cavitation is a key pathological feature of human tuberculosis (TB), and is a well-recognized risk factor for transmission of infection...

... directly in whole animals. CLARITY and PACT-based clearing of whole adult zebrafish and Mycobacterium tuberculosis -infected mouse lungs enables imaging of mycobacterial granulomas deep within tissue to a depth of more than 1 mm. Using established transgenic lines, we were able to image normal...

...Muhammad K. K. Niazi; Nimit Dhulekar; Diane Schmidt; Samuel Major; Rachel Cooper; Claudia Abeijon; Daniel M. Gatti; Igor Kramnik; Bulent Yener; Metin Gurcan; Gillian Beamer ABSTRACT Pulmonary tuberculosis (TB) is caused by Mycobacterium tuberculosis in susceptible humans . Here, we infected...

...Jean-Philippe Lanoix; Anne J. Lenaerts; Eric L. Nuermberger ABSTRACT Mice are the most commonly used species for non-clinical evaluations of drug efficacy against tuberculosis (TB). Unlike commonly used strains, C3HeB/FeJ mice develop caseous necrosis in the lung, which might alter...

...Scott M. Irwin; Emily Driver; Edward Lyon; Christopher Schrupp; Gavin Ryan; Mercedes Gonzalez-Juarrero; Randall J. Basaraba; Eric L. Nuermberger; Anne J. Lenaerts ABSTRACT Cost-effective animal models that accurately reflect the pathological progression of pulmonary tuberculosis are needed...

..., showing that the recombinant proteins exerted a Cxcr3.2-dependent chemoattraction when locally administrated in vivo . During infection of zebrafish embryos with Mycobacterium marinum , a well-established model for tuberculosis, we found that Cxcr3.2 deficiency limited the macrophage-mediated...

...Lisanne M. van Leeuwen; Martijn van der Kuip; Sameh A. Youssef; Alain de Bruin; Wilbert Bitter; A. Marceline van Furth; Astrid M. van der Sar Tuberculous meningitis (TBM) is one of the most severe extrapulmonary manifestations of tuberculosis, with a high morbidity and mortality. Characteristic...

...Mark R. Cronan; David M. Tobin Despite efforts to generate new vaccines and antibiotics for tuberculosis, the disease remains a public health problem worldwide. The zebrafish Danio rerio has emerged as a useful model to investigate mycobacterial pathogenesis and treatment. Infection of zebrafish...

...://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Usher syndrome Cancer Individualized medicine Muscular dystrophy Tuberculosis Since its establishment as a vertebrate model...

...Venkata Ramanarao Parasa; Muhammad Jubayer Rahman; Anh Thu Ngyuen Hoang; Mattias Svensson; Susanna Brighenti; Maria Lerm ABSTRACT The widely used animal models for tuberculosis (TB) display fundamental differences from human TB. Therefore, a validated model that recapitulates human lung TB...