... the brain methylomes and brain transcriptomes of adult wild-type and GR-mutant zebrafish, and identified 249 differentially methylated regions (DMRs) that are regulated by GR. These include a cluster of CpG sites within the first intron of fkbp5 , the gene encoding the glucocorticoid-inducible heat shock...

... novel biological mechanisms and genetic determinants underlying GD. Here, we combined bioinformatic analyses of immortalized and primary embryonic GnRH neuron transcriptomes with exome sequencing from GD patients to identify candidate genes implicated in the pathogenesis of GD. Among differentially...

... characterization and transcriptomic properties of gnrh neurons derived from human stem cells . Endocrinology 162 , bqab120 . 10.1210/endocr/bqab120 Kumamoto , T. and Hanashima , C. ( 2017 ). Evolutionary conservation and conversion of Foxg1 function in brain development . Dev. Growth...

... is a hallmark of hypermanganesemia with dystonia 2, an inherited manganese transporter defect caused by mutations in SLC39A14. To identify novel potential targets of manganese neurotoxicity, we performed transcriptome analysis of slc39a14 −/− mutant zebrafish that were exposed to MnCl 2 . Differentially...

... are unique genetic models of severe hypertension and cardiovascular complications. By integrating whole-genome sequencing, transcriptome profiling, genome-wide linkage scans (maximum n =1415), fine congenic mapping (maximum n =8704), pharmacological intervention and comparative analysis with transcriptome...

... in the neuronal progenitor pool led to upregulation of 37 genes expressed both in progenitors and in TdTomato-expressing GnRH neurons, which suggests upstream regulation of these genes by FGF8 signaling during GnRH neuron differentiation. These results illustrate how hPSC-derived human GnRH neuron transcriptomic...

... phenotypes. eQTL Diabetes mellitus Goto-Kakizaki rat SNP Spontaneously hypertensive rat Systems genetics Transcriptome Wellcome Trust 075491/Z/04, 057733 Seventh Framework Programme 10.13039/100011102 HEALTH-F4-2010-241504 Fondation pour la Recherche Médicale...

... revealed transcriptomic changes in mandibular bone at embryonic day 16.5 (E16.5), highlighting increased expression of genes related to osteoclast differentiation and dysregulated genes active in bone mineralization. Increased osteoclastic activity was corroborated by TRAP assay and in situ hybridization...

... is hindered by a paucity of data and is therefore often generalized from research conducted in skin and other mucosal systems. Here, using a previously validated rat injury model, expression microarray technology and an empirical Bayes analysis approach, we generated a VF-specific transcriptome dataset...