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Keywords: Trans-synaptic signaling
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Journal Articles
In collection:
Drosophila as a Disease Model
William M. Parkinson, Michelle Dookwah, Mary Lynn Dear, Cheryl L. Gatto, Kazuhiro Aoki, Michael Tiemeyer, Kendal Broadie
Journal:
Disease Models & Mechanisms
Dis Model Mech (2016) 9 (5): 513–527.
Published: 1 May 2016
... signaling by the Wnt protein Wingless (Wg) depends on the heparan sulfate proteoglycan (HSPG) co-receptor Dally-like protein (Dlp), which is regulated by synaptic MMP activity. Loss of synaptic MMP2, Wg ligand, Dlp co-receptor and downstream trans-synaptic signaling occurs with PMM2 knockdown. Taken...
Journal Articles
Journal:
Disease Models & Mechanisms
Dis Model Mech (2014) 7 (12): 1365–1378.
Published: 1 December 2014
... overexpression. Synaptogenesis relies on trans-synaptic signals modulated by this synaptomatrix carbohydrate environment, and dGALT -null NMJs display striking changes in heparan sulfate proteoglycan (HSPG) co-receptor and Wnt ligand levels, which are also corrected by dGALK co-removal and sugarless...
