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Keywords: Tolerance
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Journal Articles
Dis Model Mech (2014) 7 (5): 503–513.
Published: 1 May 2014
... known as central immune tolerance. However, low-affinity self-reactive T and B cells escape central tolerance and enter the blood and tissues, where they are kept in check by complex and non-redundant peripheral tolerance mechanisms. Dysfunction or imbalance of the immune system can lead to autoimmunity...