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Keywords: Tissue-specific knockout
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Journal Articles
Dis Model Mech (2018) 11 (3): dmm033027.
Published: 28 March 2018
... transgenic zebrafish line. To disrupt mitochondrial function genetically, we established a gateway system harboring the CRISPR/Cas9 elements for tissue-specific knockout. In a transgenic line, neutrophil-specific disruption of mitochondrial DNA polymerase, polg , significantly reduced the velocity...
Includes: Supplementary data