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Keywords: Therapy
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Journal Articles
Dis Model Mech (2022) 15 (8): dmm049059.
Published: 29 August 2022
... traits of cell senescence in the lumbar spinal cord, with selective sensitivity to senolytic treatments. Amyotrophic lateral sclerosis Navitoclax Senolytic Neuroinflammation Therapy Cell cycle Cryptic exon Instituto de Salud Carlos III http://dx.doi.org/10.13039/501100004587 PI...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2022) 15 (7): dmm049284.
Published: 25 July 2022
...Suzie Buono; Arnaud Monseur; Alexia Menuet; Anne Robé; Catherine Koch; Jocelyn Laporte; Leen Thielemans; Marion Depla; Belinda S. Cowling ABSTRACT Generating reliable preclinical data in animal models of disease is essential in therapy development. Here, we performed statistical analysis and joint...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (2): dmm041434.
Published: 24 October 2019
...Belinda S. Cowling; Leen Thielemans ABSTRACT Although around half of US Food and Drug Administration (FDA)-approved drugs originate from discoveries made in academic research laboratories, the US National Institutes of Health (NIH) estimates that nearly 90% of therapies developed in preclinical...