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Keywords: TGFβ signaling
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Journal Articles
Maryline Abrial, Sandeep Basu, Mengmeng Huang, Vincent Butty, Asya Schwertner, Spencer Jeffrey, Daniel Jordan, Caroline E. Burns, C. Geoffrey Burns
Journal:
Disease Models & Mechanisms
Dis Model Mech (2022) 15 (3): dmm046979.
Published: 28 March 2022
... growth factor beta (TGFβ) signaling play a causal or contributory role, respectively. Despite the advantages of cross-species disease modeling, animal models of aortic root aneurysm are largely restricted to genetically engineered mice. Here, we report that zebrafish devoid of the genes encoding latent...
Includes: Supplementary data
Journal Articles
Journal:
Disease Models & Mechanisms
Dis Model Mech (2019) 12 (11): dmm041228.
Published: 11 November 2019
... is characterized by localized bleeding in the germinal matrix (GM), due to inherent vessel fragility unique to this developing brain region. Studies have shown that reduced TGFβ signaling contributes to this vascular immaturity. We have previously shown that a region-specific G-protein-coupled receptor pathway...
Includes: Supplementary data