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Keywords: TDP-43
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Journal Articles
Dis Model Mech (2024) 17 (5): dmm050638.
Published: 29 May 2024
... disease. However, few studies have investigated whether the miRNA dysregulation originates from microglia. Furthermore, TDP-43 (encoded by TARDBP ), involved in miRNA biogenesis, aggregates in tissues of ∼98% of ALS cases. Thus, this study aimed to determine whether expression of the ALS-linked TDP-43...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2024) 17 (3): dmm050473.
Published: 28 March 2024
... in vivo and found that Dendra2::tau turned over faster than the relatively stable Dendra2. Furthermore, Dendra2::tau turnover was dependent on the protein expression level and independent of co-expression with human TDP-43 (officially known as TARDBP), an aggregating protein interacting with pathological...
Includes: Supplementary data
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Dis Model Mech (2019) 12 (8): dmm039552.
Published: 16 August 2019
... in the expression of mitochondrial genes and a susceptibility to oxidative stress, indicating that mitochondrial dysfunction may be a critical feature of C9-ALS skeletal muscle pathology. Finally, the C9-ALS myocytes had increased expression and aggregation of TDP-43. Together, these data show that skeletal muscle...
Includes: Supplementary data
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Journal Articles
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Dis Model Mech (2014) 7 (10): 1175–1184.
Published: 1 October 2014
.... FUS Hsp104 TDP-43 α-synuclein Disaggregase Neurodegeneration Fatal neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), Parkinson disease (PD), Huntington disease (HD) and Alzheimer disease (AD) are classified as protein-misfolding disorders ( Cushman et al., 2010...