...Hae-Young Lopilly Park; Si Won Kim; Jie Hyun Kim; Chan Kee Park ABSTRACT The dendrites of retinal ganglion cells (RGCs) synapse with the axon terminals of bipolar cells in the inner plexiform layer (IPL). Changes in the RGC dendrites and synapses between the bipolar cells in the inner retinal layer...

...Tongcui Jiang; Emily Handley; Mariana Brizuela; Edgar Dawkins; Katherine E. A. Lewis; Rosemary M. Clark; Tracey C. Dickson; Catherine A. Blizzard ABSTRACT Altered cortical excitability and synapse dysfunction are early pathogenic events in amyotrophic lateral sclerosis (ALS) patients and animal...

... category, caused by phosphomannomutase-2 mutation, and reveals a synaptic mechanism underlying associated neurological impairments. Synapse Neurotransmission Neuromuscular junction Synaptomatrix Matrix metalloproteinase Wnt Trans-synaptic signaling National Institutes of Health...

... Synapse NMII Non-muscle myosin II (NMII) is a major contributor to cellular organization, polarity and regulation, with altered NMII activity contributing to numerous disease pathologies. NMII crosslinks and slides actin filaments past each other, contracting them into actomyosin filament bundles...

... of the pathophysiological consequences. Using the fly neuromuscular system as a model for excitatory glutamatergic synapses, we show that removal of RSK function causes distinct defects in motoneurons and at the neuromuscular junction. Based on histochemical and electrophysiological analyses, we conclude that RSK...

... of Health, grant R21 RR026074 to D.R.M., and from the National Science Foundation IOS 1256114 to D.R.M. References Ashley   J. , Packard   M. , Ataman   B. , Budnik   V. ( 2005 ). Fasciclin II signals new synapse formation through amyloid precursor protein and the scaffolding protein...