... work is properly attributed. Summary: We used a zebrafish larval model to perform drug screening to identify novel and translational compounds for ameliorating brain damage after a haemorrhage, which may support neuroprotective therapeutic development. Zebrafish Stroke Intracerebral...

...Pragati Kakkar; Tarun Kakkar; Tufail Patankar; Sikha Saha ABSTRACT A stroke occurs when the blood flow to the brain is suddenly interrupted, depriving brain cells of oxygen and glucose and leading to further cell death. Neuroimaging techniques, such as computed tomography and magnetic resonance...

... heterotrimers. We define parameters for reducing stroke and myopathy in Col4a1 mutant mice by pharmacologically promoting heterotrimer secretion. Cerebral small vessel disease Stroke Intracerebral hemorrhage Collagen COL4A1 Myopathy Drug therapy Chaperones National Institutes of Health...

...Michael J. Haley; Graham Mullard; Katherine A. Hollywood; Garth J. Cooper; Warwick B. Dunn; Catherine B. Lawrence ABSTRACT Obesity is an independent risk factor for stroke, although several clinical studies have reported that obesity improves stroke outcome. Obesity is hypothesised to aid recovery...

...Ran Yang; Yunpei Zhang; Dandan Huang; Xiao Luo; Liangren Zhang; Xiaojun Zhu; Xiaolin Zhang; Zhenming Liu; Jing-Yan Han; Jing-Wei Xiong ABSTRACT Hemorrhagic stroke accounts for 10-15% of all strokes and is strongly associated with mortality and morbidity worldwide, but its prevention and therapeutic...

.... Administration of CsA in vitro or in vivo promotes the survival of NPCs and expands the pools of NPCs in mice. Moreover, CsA administration is effective in promoting NPC activation, tissue repair and functional recovery in a mouse model of cortical stroke. The mechanism(s) by which CsA mediates this cell...