...: This At a Glance article reviews how biological resilience mechanisms act across scales to protect organisms from harmful insults, focusing on the challenges and opportunities for harnessing this remarkable phenomenon therapeutically. Stress adaptation Hormesis Cytoprotection Cell survival Degenerative...

... enhances the ability of cells to tolerate these stresses through multiple mechanisms. Many of these oncogenic, RAS-driven, stress-adaptive mechanisms have also been implicated in tolerance and resistance to chemotherapy and to therapies that target the RAS pathway. Understanding how oncogenic RAS shapes...