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Keywords: Stereocilia staircase
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Journal Articles
CIB2 function is distinct from that of whirlin in the organization of sterocilia architecture
Open AccessArnaud P. J. Giese, Andrew Parker, Sakina Rehman, Steve D. M. Brown, Saima Riazuddin, Craig W. Vander Kooi, Michael R. Bowl, Zubair M. Ahmed
Journal:
Disease Models & Mechanisms
Dis Model Mech (2025) 18 (3): dmm052043.
Published: 3 April 2025
... for stereocilia staircase architecture of cochlear hair cells. Here, we refine the interaction domains of both proteins and show that these proteins play unique roles in stereocilia bundle formation and organization. We found that the EF2 domain of CIB2 binds to the HHD2 region of WHRN. AlphaFold2 multimer...
Includes: Supplementary data