... to structural changes in the myocardium or as a result of HCM cardiomyocyte electrophysiology. In this study, we used an induced pluripotent stem cell model of the R403Q variant in myosin heavy chain 7 ( MYH7 ) to study the electrophysiology of HCM cardiomyocytes in electrically coupled syncytia, revealing...

...Cody Juguilon; Joseph C. Wu ABSTRACT Human stem cell-based modeling systems are valuable tools that can greatly improve the clinical translation of basic research. Importantly, the successful application of human stem cell-based models to biomedical research depends on the widespread adoption...

... regulation. Yet, little is known about the direct impact of PNECs on respiratory diseases. In this Review, we summarise the current associations of PNECs with lung pathologies, focusing on how new experimental disease models, such as organoids derived from human pluripotent stem cells or tissue stem cells...

... that co-segregates with XLID and epileptic seizures, and results in loss of catalytic activity. Colonies formed by mouse embryonic stem cells carrying OGT C921Y showed decreased levels of protein O -GlcNAcylation accompanied by decreased levels of Oct4 (encoded by Pou5f1 ), Sox2 and extracellular alkaline...

...Dah-Jiun Fu; Andrea J. De Micheli; Mallikarjun Bidarimath; Lora H. Ellenson; Benjamin D. Cosgrove; Andrea Flesken-Nikitin; Alexander Yu. Nikitin ABSTRACT Humans and mice have cyclical regeneration of the endometrial epithelium. It is expected that such regeneration is ensured by tissue stem cells...

..., which are caused by dysfunction of the ECM receptor α-dystroglycan. However, opportunities to study the basal lamina in various human disease tissues are restricted owing to its limited accessibility. Here, we report the generation of embryoid bodies from human induced pluripotent stem cells that model...

...Madeline A. Lancaster; Meritxell Huch ABSTRACT The past decade has seen an explosion in the field of in vitro disease modelling, in particular the development of organoids. These self-organizing tissues derived from stem cells provide a unique system to examine mechanisms ranging from organ...

... of dedifferentiation and redifferentiation can promote tumorigenesis in the skin and intestine, showing how plasticity in these continuously renewing tissues might contribute to tumorigenesis. Dedifferentiation Paligenosis Plasticity Regeneration Stem cells Tumorigenesis NIDDK 10.13039/100000062...

... and proteomic screens with exposure to human carcinogen type 1A agent cadmium (Cd), we showed that many TSGs have a function in stem cells and that, in general, exposure to Cd accelerated the onset and increased the severity of the observed phenotype. This suggested that the interaction between environmental...

.... Understanding the extent of cell plasticity and uncovering its underlying mechanisms may help us refine important theories about the origin and progression of cancer, such as the cancer stem cell model, as well as the multi-hit model of tumorigenesis. Ultimately, we hope that the new concepts and perspectives...

... attributed. Editors’ choice: This study demonstrates neurogenic alterations in the most common neurodegenerative disease of children and reports a novel function of the CLN5 protein. Neurogenesis Neuronal ceroid lipofuscinoses Batten disease Lysosomal storage disease Stem cells CLN5...

...Hongjie Li; Heinrich Jasper ABSTRACT The gastrointestinal tract of complex metazoans is highly compartmentalized. It is lined by a series of specialized epithelia that are regenerated by specific populations of stem cells. To maintain tissue homeostasis, the proliferative activity of stem...

...Yunting Zhou; Qi Hu; Fuyi Chen; Juan Zhang; Jincheng Guo; Hongwu Wang; Jiang Gu; Lian Ma; Guyu Ho ABSTRACT Human umbilical cord matrix-derived stem cells (uMSCs), owing to their cellular and procurement advantages compared with mesenchymal stem cells derived from other tissue sources...

.... Regenerative medicine Stem cells Magnetic resonance imaging Paramagnetic contrast agents CEST Perfluorocarbon particles Biosensor Cell labeling Cellular function MRI is an ideal tool for the in vivo tracking and ‘sensing’ of engrafted cells because of its ability to image deep inside tissue...