... analysis of tools and approaches to study lipid droplet dynamics in the zebrafish larval liver under physiological and pathological conditions. Lipid droplet Liver disease Steatosis Zebrafish Yayasan Dayadiri University of Melbourne http://dx.doi.org/10.13039/501100001782...

...Mugagga Kalyesubula; Ramgopal Mopuri; Jimmy Asiku; Alexander Rosov; Sara Yosefi; Nir Edery; Samuel Bocobza; Uzi Moallem; Hay Dvir ABSTRACT Fatty liver is an abnormal metabolic condition of excess intrahepatic fat. This condition, referred to as hepatic steatosis, is tightly associated with chronic...

... of AH in mice and compared the nature of liver injury in C57/BL6 wild-type (WT) versus Nrf2 −/− mice. Our data showed that both WT and Nrf2 −/− mice demonstrate robust weight loss, and an increase in serum transaminase, steatosis and hepatic inflammation when exposed to diet and ethanol...

... to rescue steatotic liver grafts, including by pharmacological defatting. In this study, we tested the potential of new drug combinations to trigger defatting in three human culture models, primary hepatocytes with induced steatosis, primary hepatocytes isolated from steatotic liver, and precision-cut liver...

... zebrafish larvae to 2% ethanol for 24 h induced hepatic steatosis, angiogenesis and fibrogenesis. The liver started self-repair once ethanol was removed. Although inhibiting Kdrl did not block the initial activation of hepatic stellate cells during ethanol treatment, it suppressed their proliferation...

... with paradoxical effects in the liver. Administration of IL-6 has been reported to confer protection against steatosis, but plasma and tissue IL-6 concentrations are elevated in chronic liver diseases, including fatty liver diseases associated with obesity and alcoholic ingestion. In this study, we further...

.... Fatty liver disease (steatosis) is associated with markers of UPR activation and robust UPR induction can cause steatosis; however, in other cases, UPR activation can protect against this disease. By assessing the magnitude of activation of UPR sensors and target genes in the liver of zebrafish larvae...