...Jade E. Varineau; Eliezer Calo ABSTRACT Disruptions in core cellular processes elicit stress responses that drive cell-state changes leading to organismal phenotypes. Perturbations in the splicing machinery cause widespread mis-splicing, resulting in p53-dependent cell-state changes that give rise...

... found in CCMS, and results in death shortly after birth. RNAseq analysis of mutant heads prior to morphological defects revealed increased exon skipping and intron retention in association with increased 5′ splice site strength. We found increased exon skipping in negative regulators of the P53 pathway...

...Shelly Sorrells; Sara Nik; Mattie Casey; Rosannah C. Cameron; Harold Truong; Cristhian Toruno; Michelle Gulfo; Albert Lowe; Cicely Jette; Rodney A. Stewart; Teresa V. Bowman ABSTRACT RNA splicing factors are essential for the viability of all eukaryotic cells; however, in metazoans some cell types...

...Irma García-Alcover; Jordi Colonques-Bellmunt; Raquel Garijo; José R. Tormo; Rubén Artero; Mari Carmen Álvarez-Abril; Arturo López Castel; Manuel Pérez-Alonso Alternative splicing of pre-mRNAs is an important mechanism that regulates cellular function in higher eukaryotes. A growing number of human...