...Shir Confino; Yair Wexler; Adar Medvetzky; Yotam Elazary; Zohar Ben-Moshe; Joel Reiter; Talya Dor; Simon Edvardson; Gali Prag; Tamar Harel; Yoav Gothilf ABSTRACT Sleep disturbances are common among children with neurodevelopmental disorders. Here, we report a syndrome characterized by prenatal...

...Luis E. Salazar Leon; Amanda M. Brown; Heet Kaku; Roy V. Sillitoe ABSTRACT Purkinje cell dysfunction disrupts movement and causes disorders such as ataxia. Recent evidence suggests that Purkinje cell dysfunction may also alter sleep regulation. Here, we used an ataxic mouse model generated...

... act as negative regulators of insulin signalling. Mammalian tribbles pseudokinase (TRIB) genes have also been linked to insulin resistance and type 2 diabetes mellitus. Type 2 diabetes mellitus is associated with increased body weight, sleep problems and increased long-term mortality. Here, we...

... erythropoiesis and megakaryopoiesis, reduced bone density, craniofacial changes, altered cardiac function, a pre-diabetic state, and deficits in memory, locomotion, hearing and sleep. Thus, Dp1Tyb mice are an excellent model for investigating complex DS phenotype-genotype relationships for this common disorder...