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Keywords: Skeletal muscle
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Journal Articles
Dis Model Mech (2023) 16 (9): dmm050092.
Published: 5 September 2023
... susceptibility of skeletal muscle defects in response to extrinsic triggers, similar to TANGO2-deficient patients. Using lipidomics, we identified alterations in the glycerolipid pathway in tango2 mutants, which is critical for membrane stability and energy balance. Therefore, these studies provide insight...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (7): dmm044867.
Published: 7 July 2020
... models, and weigh up their advantages and disadvantages. Generating skeletal muscle tissue in vitro is a multi-step process. First, mononuclear skeletal myoblasts are seeded on a standard culture surface that is often coated with extracellular matrix (ECM) proteins, such as collagen or laminin...
Journal Articles
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Cancer Metabolism
Dis Model Mech (2020) 13 (1): dmm043166.
Published: 24 January 2020
...Joshua R. Huot; Leah J. Novinger; Fabrizio Pin; Andrea Bonetto ABSTRACT Colorectal cancer (CRC) is often accompanied by formation of liver metastases (LM) and skeletal muscle wasting, i.e. cachexia. Despite affecting the majority of CRC patients, cachexia remains underserved, understudied...
Journal Articles
Dis Model Mech (2019) 12 (12): dmm041368.
Published: 19 December 2019
...Aurora Fusto; Louise A. Moyle; Penney M. Gilbert; Elena Pegoraro ABSTRACT The core myopathies are a group of congenital myopathies with variable clinical expression – ranging from early-onset skeletal-muscle weakness to later-onset disease of variable severity – that are identified...
Journal Articles
Dis Model Mech (2019) 12 (8): dmm039552.
Published: 16 August 2019
... from respiratory complications on average only 2-5 years after diagnosis. There is increasing evidence that skeletal muscle is affected early in the disease process, yet the pathological processes occurring in the skeletal muscle of ALS patients are still mostly unknown. Specifically, the most common...
Includes: Supplementary data
Journal Articles
Journal Articles
Dis Model Mech (2017) 10 (8): 943–954.
Published: 1 August 2017
... Combinatorial therapies Skeletal muscle Spinal muscular atrophy Survival motor neuron Spinal muscular atrophy (SMA) is the most common genetic disease resulting in death in infancy, affecting approximately 1 in 6000 to 1 in 10,000 births ( Crawford and Pardo, 1996 ). This autosomal recessive disorder...
Journal Articles
Journal Articles
Journal Articles
Dis Model Mech (2015) 8 (9): 1059–1069.
Published: 1 September 2015
...Jae-Sung You; Garrett B. Anderson; Matthew S. Dooley; Troy A. Hornberger ABSTRACT The maintenance of skeletal muscle mass contributes substantially to health and to issues associated with the quality of life. It has been well recognized that skeletal muscle mass is regulated by mechanically induced...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (8): 999–1009.
Published: 1 August 2015
...), in their slow-twitch type I skeletal muscle fibers to determine the effects on SERCA function. As expected with a 6- to 7-fold overexpression of phospholamban, SERCA dysfunction was evident in Pln OE muscles, with marked reductions in rates of Ca 2+ uptake, maximal ATPase activity and the apparent affinity...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2014) 7 (4): 471–481.
Published: 1 April 2014
... naturally inhibits skeletal muscle growth by binding to ActRIIB, a receptor on the cell surface of myofibers. Because blocking myostatin in an adult wild-type mouse induces profound muscle hypertrophy, we applied a soluble ActRIIB receptor to models of disuse (limb immobilization) and denervation (sciatic...
Includes: Supplementary data