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Keywords: Single-cell RNA sequencing
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Journal Articles

Disruption of Morrbid alleviates autoinflammatory osteomyelitis in Pstpip2 -deficient mice

Open Access
In collection:
Rare Disease Translational Research
Qingran Huo, Jiayu Ding, Hongxi Zhou, Yue Wang, Shanshan Wang, Hang He, Lorie Chen Cai, Jingjing Liu, Ge Dong, Zhigang Cai
Journal: Disease Models & Mechanisms
Dis Model Mech (2025) 18 (7): dmm052176.
https://doi.org/10.1242/dmm.052176
Published: 7 July 2025
... attributed. Summary: Using single-cell RNA-sequencing analysis and knockout of Morrbid in Pstpip2 −/− mice, we show that reducing the lifespan of inflammatory myeloid cells by targeting Morrbid can be an effective therapy for chronic osteomyelitis. Autoinflammatory diseases Chronic...
View article titled, Disruption of Morrbid alleviates autoinflammatory osteomyelitis in Pstpip2 -deficient mice
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Includes: Supplementary data
Journal Articles

Microvascular aberrations found in human polycystic kidneys are an early feature in a Pkd1 mutant mouse model

Open Access
Daniyal J. Jafree, Charith Perera, Mary Ball, Daniele Tolomeo, Gideon Pomeranz, Laura Wilson, Benjamin Davis, William J. Mason, Eva Maria Funk, Maria Kolatsi-Joannou, Radu Polschi, Saif Malik, Benjamin J. Stewart, Karen L. Price, Hannah Mitchell, Reza Motallebzadeh, Yoshiharu Muto, Robert Lees, Sarah Needham, Dale Moulding, Jennie C. Chandler, Sonal Nandanwar, Claire L. Walsh, Paul J. D. Winyard, Peter J. Scambler, René Hägerling, Menna R. Clatworthy, Benjamin D. Humphreys, Mark F. Lythgoe, Simon Walker-Samuel, Adrian S. Woolf, David A. Long
Journal: Disease Models & Mechanisms
Dis Model Mech (2025) 18 (4): dmm052024.
https://doi.org/10.1242/dmm.052024
Published: 28 April 2025
... found to precede excretory kidney failure. Magnetic resonance imaging Nephrology Perfusion Single-cell RNA sequencing Three-dimensional microscopy Vasculature Rosetrees Trust http://dx.doi.org/10.13039/501100000833 PhD2020\100012 Foulkes Foundation http://dx.doi.org...
View article titled, Microvascular aberrations found in human polycystic kidneys are an early feature in a Pkd1 mutant mouse model
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Includes: Supplementary data