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Keywords: Signaling
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Journal Articles
Dis Model Mech (2022) 15 (8): dmm049591.
Published: 16 August 2022
... prognosis. To study ALK-activating mutations in a genetically controllable system, we employed CRIPSR/Cas9, incorporating orthologs of the human oncogenic mutations ALK F1174L and ALK Y1278S in the Drosophila Alk locus. Alk F1251L and Alk Y1355S mutant Drosophila exhibited enhanced Alk signaling phenotypes...
Includes: Supplementary data
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The RAS Pathway
Dis Model Mech (2022) 15 (2): dmm049229.
Published: 3 March 2022
... activation in human cancer, and highlights recent advances towards its therapeutic inhibition, using melanoma as an example. Cancer genetics Melanoma RAS pathway Signaling Targeted therapies Centre National de la Recherche Scientifique http://dx.doi.org/10.13039/501100004794...
Journal Articles