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1-3 of 3
Keywords: Signaling
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Journal Articles
Patient-associated mutations in Drosophila Alk perturb neuronal differentiation and promote survival
Kathrin Pfeifer, Georg Wolfstetter, Vimala Anthonydhason, Tafheem Masudi, Badrul Arefin, Mats Bemark, Patricia Mendoza-Garcia, Ruth H. Palmer
Journal:
Disease Models & Mechanisms
Dis Model Mech (2022) 15 (8): dmm049591.
Published: 16 August 2022
... prognosis. To study ALK-activating mutations in a genetically controllable system, we employed CRIPSR/Cas9, incorporating orthologs of the human oncogenic mutations ALK F1174L and ALK Y1278S in the Drosophila Alk locus. Alk F1251L and Alk Y1355S mutant Drosophila exhibited enhanced Alk signaling phenotypes...
Includes: Supplementary data
Journal Articles
In collection:
The RAS Pathway
Journal:
Disease Models & Mechanisms
Dis Model Mech (2022) 15 (2): dmm049229.
Published: 3 March 2022
... activation in human cancer, and highlights recent advances towards its therapeutic inhibition, using melanoma as an example. Cancer genetics Melanoma RAS pathway Signaling Targeted therapies Centre National de la Recherche Scientifique http://dx.doi.org/10.13039/501100004794...
Journal Articles
Christian Klopsch, Anna Skorska, Marion Ludwig, Heiko Lemcke, Gabriela Maass, Ralf Gaebel, Martin Beyer, Cornelia Lux, Anita Toelk, Karina Müller, Christian Maschmeier, Sarah Rohde, Petra Mela, Brigitte Müller-Hilke, Stefan Jockenhoevel, Brigitte Vollmar, Robert Jaster, Robert David, Gustav Steinhoff
Journal:
Disease Models & Mechanisms
Dis Model Mech (2018) 11 (6): dmm033282.
Published: 22 June 2018
... Steinhoff ABSTRACT Ischemic heart failure is the leading cause of mortality worldwide. An early boost of intracardiac regenerative key mechanisms and angiogenetic niche signaling in cardiac mesenchymal stem cells (MSCs) could improve myocardial infarction (MI) healing. Epicardial erythropoietin (EPO; 300 U...
Includes: Supplementary data