... animal can also be challenging: for most mammals, a sexually dimorphic appearance is apparent when the animals are adults, but sex can be difficult to detect in pre-pubescent or embryonic stages. Examining the sex of mammalian embryos requires researchers to determine the presence of the Y chromosome...

... to canonical WNT signaling-induced hyperplasia. To explain sexual dimorphism in adrenocortical hyperplasia, it is essential to dissect the role of sex hormones versus the role of sex chromosomes. We took advantage of a sex reversal model in which constitutive ectopic expression of a Wt1-Sox9 gene in XX...

... microscopy and Raman spectroscopy identified unique, sexually dimorphic extracellular matrix signatures linking pathological matrix disorganisation with composition. Polarisation-resolved second-harmonic generation Raman spectroscopy Sexual dimorphism Extracellular matrix Collagen VEGF...