... and osteoclastogenesis. Furthermore, osteoblast senescence was increased. To date, there are only a few studies suggesting a causal association between mtROS and cellular senescence in tissue in vivo . Targeting SOD2 to improve redox homeostasis could represent a potential therapeutic strategy for maintaining bone...

... and a substantially reduced number of offspring. Like G130V in FRDA, the G127V mutation results in a dramatic decrease of Fxn protein without affecting transcript synthesis or splicing. Fxn G127V mouse embryonic fibroblasts exhibit significantly reduced proliferation and increased cell senescence. These defects...