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Keywords: Seipin
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Journal Articles

Identification of genetic suppressors for a BSCL2 lipodystrophy pathogenic variant in Caenorhabditis elegans

In collection:
Rare Disease Translational Research
Xiaofei Bai, Harold E. Smith, Andy Golden
Journal: Disease Models & Mechanisms
Dis Model Mech (2024) 17 (6): dmm050524.
https://doi.org/10.1242/dmm.050524
Published: 16 April 2024
...Xiaofei Bai; Harold E. Smith; Andy Golden ABSTRACT Seipin (BSCL2), a conserved endoplasmic reticulum protein, plays a critical role in lipid droplet (LD) biogenesis and in regulating LD morphology, pathogenic variants of which are associated with Berardinelli–Seip congenital generalized...
View articletitled, Identification of genetic suppressors for a BSCL2 lipodystrophy pathogenic variant in Caenorhabditis elegans
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Includes: Supplementary data
Journal Articles

Seipin knockout in mice impairs stem cell proliferation and progenitor cell differentiation in the adult hippocampal dentate gyrus via reduced levels of PPARγ

Guoxi Li, Libin Zhou, Ying Zhu, Conghui Wang, Sha Sha, Xunde Xian, Yong Ji, George Liu, Ling Chen
Journal: Disease Models & Mechanisms
Dis Model Mech (2015) 8 (12): 1615–1624.
https://doi.org/10.1242/dmm.021550
Published: 1 December 2015
...Guoxi Li; Libin Zhou; Ying Zhu; Conghui Wang; Sha Sha; Xunde Xian; Yong Ji; George Liu; Ling Chen ABSTRACT The seipin gene ( BSCL2 ) was originally identified in humans as a loss-of-function gene associated with congenital generalized lipodystrophy type 2 (CGL2). Neuronal seipin-knockout (seipin...
View articletitled, Seipin knockout in mice impairs stem cell proliferation and progenitor cell differentiation in the adult hippocampal dentate gyrus via reduced levels of PPARγ
Open the PDF for Seipin knockout in mice impairs stem cell proliferation and progenitor cell differentiation in the adult hippocampal dentate gyrus via reduced levels of PPARγ in another window
Includes: Supplementary data