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Keywords: Rotenone
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Journal Articles

The rat rotenone model reproduces the abnormal pattern of central catecholamine metabolism found in Parkinson's disease

Open Access
In collection:
Neurodegenerative Disorders , Rat as a Disease Model
Regev Landau, Reut Halperin, Patti Sullivan, Zion Zibly, Avshalom Leibowitz, David S. Goldstein, Yehonatan Sharabi
Journal: Disease Models & Mechanisms
Dis Model Mech (2022) 15 (1): dmm049082.
https://doi.org/10.1242/dmm.049082
Published: 24 January 2022
... that reproduces this abnormal catecholamine neurochemical pattern. Adult rats received subcutaneous vehicle or the mitochondrial complex 1 inhibitor rotenone (2 mg/kg/day via a minipump) for 10 days. Locomotor activity was recorded, and striatal tissue sampled for catechol contents and catechol ratios...
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Journal Articles

Pituitary adenylate cyclase-activating polypeptide (PACAP) has a neuroprotective function in dopamine-based neurodegeneration in rat and snail parkinsonian models

Open Access
In collection:
Neurodegenerative Disorders , Rat as a Disease Model
Gabor Maasz, Zita Zrinyi, Dora Reglodi, Dora Petrovics, Adam Rivnyak, Tibor Kiss, Adel Jungling, Andrea Tamas, Zsolt Pirger
Journal: Disease Models & Mechanisms
Dis Model Mech (2017) 10 (2): 127–139.
https://doi.org/10.1242/dmm.027185
Published: 1 February 2017
...-dopamine (6-OHDA) in rat parkinsonian models. Recently, we investigated the molecular background of the neuroprotective effect of PACAP in dopamine (DA)-based neurodegeneration using rotenone-induced snail and 6-OHDA-induced rat models of Parkinson's disease. Behavioural activity, monoamine (DA...
View article titled, Pituitary adenylate cyclase-activating polypeptide (PACAP) has a neuroprotective function in dopamine-based neurodegeneration in rat and snail parkinsonian models
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Includes: Supplementary data