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Keywords: Respiratory chain complex
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Journal Articles
In collection:
Neurodegenerative Disorders
Hong Lin, Jordi Magrane, Amy Rattelle, Anna Stepanova, Alexander Galkin, Elisia M. Clark, Yi Na Dong, Sarah M. Halawani, David R. Lynch
Journal:
Disease Models & Mechanisms
Dis Model Mech (2017) 10 (11): 1343–1352.
Published: 1 November 2017
... transgene, we show early cerebellar deficits in mitochondrial biogenesis and respiratory chain complexes in this FRDA model. At asymptomatic stages, the levels of PGC-1α (PPARGC1A), the mitochondrial biogenesis master regulator, are significantly decreased in cerebellar homogenates of KIKO mice compared...
Includes: Supplementary data
