... mutant mice and was rapidly cleared from the brain and plasma with a half-life of ∼2 h. Chronic intermittent treatment of Mecp2 mutants with a low dose of PTX-BD4-3 (5 mg/kg, intraperitoneally, once every 3 days for 8 weeks) reversed deficits in two core RTT symptom domains – respiration and motor...

... mitochondrial respiration, the loss or reduction of function of DJ-1 in Parkinson's disease cells produces defects in particular endocytic pathways, downstream vesicle trafficking and related processes. At least 17 other Parkinson's disease-related proteins also play normal and cytopathological roles...

... of post-mortem Parkinson's disease (PD) brains, pharmacological and genetic models of PD have suggested that two fundamental interacting cellular processes are impaired – proteostasis and mitochondrial respiration. We have re-examined the role of mitochondrial dysfunction in lymphoblasts isolated from...

... neurochemical dysfunction in the respiratory network after birth . Respir. Physiol. Neurobiol.   168 , 101 – 108 . Katz   D. M. , Berger-Sweeney   J. E. , Eubanks   J. H. , Justice   M. J. , Neul   J. L. , Pozzo-Miller   L. , Blue   M. E. , Christian   D. , Crawley   J. N...