... in different genes, including REN , encoding renin. Renin is a secreted protease composed of three domains: the leader peptide that allows insertion in the endoplasmic reticulum (ER), a pro-segment regulating its activity, and the mature part of the protein. Mutations in mature renin lead to ER retention...

...Brian Chipman Belyea; Fang Xu; Maria Luisa Soledad Sequeira-Lopez; Roberto Ariel Gomez ABSTRACT Conditional deletion of RBP-J , the major transcriptional effector of Notch signaling, specifically within renin-expressing cells leads to the development of B-cell leukemia. However, the influence...