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Keywords: Regeneration
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Journal Articles
Dis Model Mech (2021) 14 (5): dmm044669.
Published: 01 June 2021
...María Losada-Pérez; Nuria García-Guillén; Sergio Casas-Tintó ABSTRACT The mammalian central nervous system (CNS) exhibits limited regenerative capacity and the mechanisms that mediate its regeneration are not fully understood. Here, we present a novel experimental design to damage the CNS by using...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (12): dmm046920.
Published: 21 December 2020
... further unveiled heterogeneous gene expression profiles in the PNEC population and revealed that a small number of PNECs undergo reprogramming during regeneration. Aberrant large clusters of PNECs have been observed in neuroendocrine tumors, including small-cell lung cancer (SCLC). Modern innovation of...
Journal Articles
Dis Model Mech (2020) 13 (5): dmm044131.
Published: 27 May 2020
... regenerate after injury. In stark contrast, the regeneration of a completely transected spinal cord and accompanying reversal of paralysis in adult zebrafish is arguably one of the most spectacular biological phenomena in nature. Here, we review reports from the last decade that dissect the mechanisms of...
Journal Articles
Dis Model Mech (2019) 12 (1): dmm036004.
Published: 23 January 2019
... Inflammation Insulin Islet Regeneration Zebrafish Beta-cells Type 1 diabetes mellitus (T1DM) is an autoimmune reaction against the insulin-producing β-cells, which leads to cytokine-mediated β-cell loss. Type 2 diabetes mellitus (T2DM) is a pandemic metabolic disorder that affects 415-million...
Includes: Supplementary data
Journal Articles
In collection:
Stem Cells
Dis Model Mech (2018) 11 (10): dmm033662.
Published: 08 October 2018
... a significant percentage of the population, including those that will go on to develop osteoarthritis (OA). Like humans, most mammals, including mice, are incapable of regenerating injured cartilage. Interestingly, it has previously been shown that p21 ( Cdkn1a ) knockout (p21 −/− ) mice demonstrate...
Includes: Supplementary data
Journal Articles
In collection:
Cancer , Stem Cells
Dis Model Mech (2018) 11 (9): dmm035071.
Published: 31 August 2018
... of dedifferentiation and redifferentiation can promote tumorigenesis in the skin and intestine, showing how plasticity in these continuously renewing tissues might contribute to tumorigenesis. Dedifferentiation Paligenosis Plasticity Regeneration Stem cells Tumorigenesis There is...
Journal Articles
In collection:
Cancer , Stem Cells
Dis Model Mech (2018) 11 (7): dmm033373.
Published: 23 July 2018
.... Indeed, we recently proposed that mature cells can become regenerative via a conserved set of molecular mechanisms (‘paligenosis’), suggesting that a program for regeneration exists alongside programs for death (apoptosis) and division (mitosis). In two Reviews describing how emerging concepts of...
Journal Articles
Dis Model Mech (2018) 11 (7): dmm033092.
Published: 06 July 2018
... regenerating injured cartilage in the first two trimesters of gestation. A deeper understanding of the properties intrinsic to the response of fetal tissue to injury would allow us to modulate the way in which adult tissue responds to injury. In this study, we employed secretome proteomics to compare fetal and...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2017) 10 (3): 307–321.
Published: 01 March 2017
...Nicole Schmitner; Kenji Kohno; Dirk Meyer ABSTRACT The exocrine pancreas displays a significant capacity for regeneration and renewal. In humans and mammalian model systems, the partial loss of exocrine tissue, such as after acute pancreatitis or partial pancreatectomy induces rapid recovery via...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2017) 10 (1): 63–76.
Published: 01 January 2017
... physiology Heart failure Regeneration Resting heart rates in adult zebrafish have been estimated to be 120-130 beats per min at 28°C ( Barrionuevo and Burggren, 1999 ; Nemtsas et al., 2010 ; Verkerk and Remme, 2012 ). Since most anesthetic agents have negative chronotropic effects...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2016) 9 (10): 1125–1137.
Published: 01 October 2016
... from such studies. Clinical trials Rat Regeneration Repair Spinal cord injury Funding Our work discussed here was supported by grants from Hjärnfonden (the Swedish Brain Foundation), Vetenskapsrådet (the Swedish Research Council; K2012-62X-03185-42-4 to L.O.), Stiftelsen för...
Journal Articles
Dis Model Mech (2016) 9 (5): 487–499.
Published: 01 May 2016
...Hongjie Li; Heinrich Jasper ABSTRACT The gastrointestinal tract of complex metazoans is highly compartmentalized. It is lined by a series of specialized epithelia that are regenerated by specific populations of stem cells. To maintain tissue homeostasis, the proliferative activity of stem and/or...
Journal Articles
Dis Model Mech (2016) 9 (3): 235–244.
Published: 01 March 2016
... accompanying poster, we highlight the physiological and molecular parallels between fly and human organs that validate the use of Drosophila to study the molecular pathogenesis underlying human diseases. Drosophila Human disease models Nervous system Neurodegeneration Regeneration Heart Liver...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (12): 1635–1641.
Published: 01 December 2015
...-deficient, ethionine-supplemented model induces liver injury in mice and reproducibly minimizes morbidity and mortality, whilst maintaining a liver-progenitor-cell response sufficient for cell-line establishment. Ductular reaction Hepatic stem cell Hepatocarcinogenesis Fatty liver Regeneration...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (6): 553–564.
Published: 01 June 2015
... in the nervous system, but the dynamic interactions between peripheral neurons and Schwann cells during injury and regeneration remain incompletely characterized. Here, we combine laser microsurgery, genetic analysis, high-resolution intravital imaging and lattice light-sheet microscopy to study the...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2014) 7 (7): 769–776.
Published: 01 July 2014
...Wolfram Goessling; Trista E. North Regenerative medicine has the promise to alleviate morbidity and mortality caused by organ dysfunction, longstanding injury and trauma. Although regenerative approaches for a few diseases have been highly successful, some organs either do not regenerate well or...
Journal Articles
Dis Model Mech (2014) 7 (6): 601–611.
Published: 01 June 2014
... ( Ambystoma mexicanum ) and mammals but show marked cross-species differences in regulation patterns following spinal cord injury. We found that precise post-injury levels of one of these miRNAs (miR-125b) is essential for functional recovery, and guides correct regeneration of axons through the lesion site...
Includes: Supplementary data