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Keywords: Regeneration
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Journal Articles
Dis Model Mech (2023) 16 (5): dmm049786.
Published: 7 November 2022
... is part of a collection ‘Moving Heart Failure to Heart Success: Mechanisms, Regeneration & Therapy’, which was launched in a dedicated Special Issue guest edited by Jeroen Bakkers, Milena Bellin and Ravi Karra. See related articles in this collection at https://journals.biologists.com/collection/8169...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2021) 14 (5): dmm044669.
Published: 1 June 2021
...María Losada-Pérez; Nuria García-Guillén; Sergio Casas-Tintó ABSTRACT The mammalian central nervous system (CNS) exhibits limited regenerative capacity and the mechanisms that mediate its regeneration are not fully understood. Here, we present a novel experimental design to damage the CNS by using...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (12): dmm046920.
Published: 21 December 2020
... further unveiled heterogeneous gene expression profiles in the PNEC population and revealed that a small number of PNECs undergo reprogramming during regeneration. Aberrant large clusters of PNECs have been observed in neuroendocrine tumors, including small-cell lung cancer (SCLC). Modern innovation...
Journal Articles
Dis Model Mech (2020) 13 (5): dmm044131.
Published: 27 May 2020
... to regenerate after injury. In stark contrast, the regeneration of a completely transected spinal cord and accompanying reversal of paralysis in adult zebrafish is arguably one of the most spectacular biological phenomena in nature. Here, we review reports from the last decade that dissect the mechanisms...
Journal Articles
Dis Model Mech (2019) 12 (1): dmm036004.
Published: 23 January 2019
... with applications in developmental and regeneration studies . Nat. Protoc.   3 , 948 - 954 . 10.1038/nprot.2008.58 Dalle , S. , Burcelin , R. and Gourdy , P. ( 2013 ). Specific actions of GLP-1 receptor agonists and DPP4 inhibitors for the treatment of pancreatic beta-cell impairments...
Includes: Supplementary data
Journal Articles
In collection:
Stem Cells
Dis Model Mech (2018) 11 (10): dmm033662.
Published: 8 October 2018
... a significant percentage of the population, including those that will go on to develop osteoarthritis (OA). Like humans, most mammals, including mice, are incapable of regenerating injured cartilage. Interestingly, it has previously been shown that p21 ( Cdkn1a ) knockout (p21 −/− ) mice demonstrate auricular...
Includes: Supplementary data
Journal Articles
In collection:
Cancer , Stem Cells
Dis Model Mech (2018) 11 (9): dmm035071.
Published: 31 August 2018
... of dedifferentiation and redifferentiation can promote tumorigenesis in the skin and intestine, showing how plasticity in these continuously renewing tissues might contribute to tumorigenesis. Dedifferentiation Paligenosis Plasticity Regeneration Stem cells Tumorigenesis Fig. 1. Possible sources...
Journal Articles
In collection:
Cancer , Stem Cells
Dis Model Mech (2018) 11 (7): dmm033373.
Published: 23 July 2018
.... Indeed, we recently proposed that mature cells can become regenerative via a conserved set of molecular mechanisms (‘paligenosis’), suggesting that a program for regeneration exists alongside programs for death (apoptosis) and division (mitosis). In two Reviews describing how emerging concepts...
Journal Articles
Dis Model Mech (2018) 11 (7): dmm033092.
Published: 6 July 2018
... of regenerating injured cartilage in the first two trimesters of gestation. A deeper understanding of the properties intrinsic to the response of fetal tissue to injury would allow us to modulate the way in which adult tissue responds to injury. In this study, we employed secretome proteomics to compare fetal...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2017) 10 (3): 307–321.
Published: 1 March 2017
...Nicole Schmitner; Kenji Kohno; Dirk Meyer ABSTRACT The exocrine pancreas displays a significant capacity for regeneration and renewal. In humans and mammalian model systems, the partial loss of exocrine tissue, such as after acute pancreatitis or partial pancreatectomy induces rapid recovery via...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2017) 10 (1): 63–76.
Published: 1 January 2017
.... ( 2015 ). High-resolution tissue Doppler imaging of the zebrafish heart during its regeneration . Zebrafish   12 , 48 - 57 . 10.1089/zeb.2014.1026 Kalam , K. , Otahal , P. and Marwick , T. H. ( 2014 ). Prognostic implications of global LV dysfunction: a systematic review...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2016) 9 (10): 1125–1137.
Published: 1 October 2016
... ). Astrocyte scar formation aids central nervous system axon regeneration . Nature   532 , 195 - 200 . 10.1038/nature17623 Angeli , C. A. , Edgerton , V. R. , Gerasimenko , Y. P. and Harkema , S. J. ( 2014 ). Altering spinal cord excitability enables voluntary movements after...
Journal Articles
Dis Model Mech (2016) 9 (5): 487–499.
Published: 1 May 2016
...Hongjie Li; Heinrich Jasper ABSTRACT The gastrointestinal tract of complex metazoans is highly compartmentalized. It is lined by a series of specialized epithelia that are regenerated by specific populations of stem cells. To maintain tissue homeostasis, the proliferative activity of stem...
Journal Articles
Dis Model Mech (2016) 9 (3): 235–244.
Published: 1 March 2016
..., we highlight the physiological and molecular parallels between fly and human organs that validate the use of Drosophila to study the molecular pathogenesis underlying human diseases. Drosophila Human disease models Nervous system Neurodegeneration Regeneration Heart Liver Oenocyte...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (12): 1635–1641.
Published: 1 December 2015
...-deficient, ethionine-supplemented model induces liver injury in mice and reproducibly minimizes morbidity and mortality, whilst maintaining a liver-progenitor-cell response sufficient for cell-line establishment. Ductular reaction Hepatic stem cell Hepatocarcinogenesis Fatty liver Regeneration...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (6): 553–564.
Published: 1 June 2015
... in the nervous system, but the dynamic interactions between peripheral neurons and Schwann cells during injury and regeneration remain incompletely characterized. Here, we combine laser microsurgery, genetic analysis, high-resolution intravital imaging and lattice light-sheet microscopy to study the interaction...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2014) 7 (7): 769–776.
Published: 1 July 2014
...Wolfram Goessling; Trista E. North Regenerative medicine has the promise to alleviate morbidity and mortality caused by organ dysfunction, longstanding injury and trauma. Although regenerative approaches for a few diseases have been highly successful, some organs either do not regenerate well...
Journal Articles
Dis Model Mech (2014) 7 (6): 601–611.
Published: 1 June 2014
... ( Ambystoma mexicanum ) and mammals but show marked cross-species differences in regulation patterns following spinal cord injury. We found that precise post-injury levels of one of these miRNAs (miR-125b) is essential for functional recovery, and guides correct regeneration of axons through the lesion site...
Includes: Supplementary data