1-19 of 19
Keywords: Regeneration
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
Dis Model Mech (2023) 16 (8): dmm050280.
Published: 2 August 2023
... , 578 - 586 . 10.1038/nn.2798 Goldman , J. A. and Poss , K. D. ( 2020 ). Gene regulatory programmes of tissue regeneration . Nat. Rev. Genet. 21 , 511 - 525 . 10.1038/s41576-020-0239-7 Hadzhiev , Y. , Wheatley , L. , Cooper , L. , Ansaloni , F...
Journal Articles
Dis Model Mech (2023) 16 (5): dmm049786.
Published: 7 November 2022
... disease. Apoptosis Cardioprotection Cardiomyocyte proliferation Cell-cycle activation Myocardial infarction Regeneration Tip60 TH1834 National Institutes of Health http://dx.doi.org/10.13039/100000002 5R01HL131788 1S10 OD025038 Cardiovascular Center, Medical College...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2021) 14 (5): dmm044669.
Published: 1 June 2021
...María Losada-Pérez; Nuria García-Guillén; Sergio Casas-Tintó ABSTRACT The mammalian central nervous system (CNS) exhibits limited regenerative capacity and the mechanisms that mediate its regeneration are not fully understood. Here, we present a novel experimental design to damage the CNS by using...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (12): dmm046920.
Published: 21 December 2020
... further unveiled heterogeneous gene expression profiles in the PNEC population and revealed that a small number of PNECs undergo reprogramming during regeneration. Aberrant large clusters of PNECs have been observed in neuroendocrine tumors, including small-cell lung cancer (SCLC). Modern innovation...
Journal Articles
Dis Model Mech (2020) 13 (5): dmm044131.
Published: 27 May 2020
... to regenerate after injury. In stark contrast, the regeneration of a completely transected spinal cord and accompanying reversal of paralysis in adult zebrafish is arguably one of the most spectacular biological phenomena in nature. Here, we review reports from the last decade that dissect the mechanisms...
Journal Articles
Dis Model Mech (2019) 12 (1): dmm036004.
Published: 23 January 2019
... Regeneration Zebrafish Beta-cells Type 1 diabetes mellitus (T1DM) is an autoimmune reaction against the insulin-producing β-cells, which leads to cytokine-mediated β-cell loss. Type 2 diabetes mellitus (T2DM) is a pandemic metabolic disorder that affects 415-million people worldwide. T2DM often...
Includes: Supplementary data
Journal Articles
In collection:
Stem Cells
Dis Model Mech (2018) 11 (10): dmm033662.
Published: 8 October 2018
... a significant percentage of the population, including those that will go on to develop osteoarthritis (OA). Like humans, most mammals, including mice, are incapable of regenerating injured cartilage. Interestingly, it has previously been shown that p21 ( Cdkn1a ) knockout (p21 −/− ) mice demonstrate auricular...
Includes: Supplementary data
Journal Articles
In collection:
Cancer , Stem Cells
Dis Model Mech (2018) 11 (9): dmm035071.
Published: 31 August 2018
... of dedifferentiation and redifferentiation can promote tumorigenesis in the skin and intestine, showing how plasticity in these continuously renewing tissues might contribute to tumorigenesis. Dedifferentiation Paligenosis Plasticity Regeneration Stem cells Tumorigenesis In Part I of this Review...
Journal Articles
In collection:
Cancer , Stem Cells
Dis Model Mech (2018) 11 (7): dmm033373.
Published: 23 July 2018
.... Indeed, we recently proposed that mature cells can become regenerative via a conserved set of molecular mechanisms (‘paligenosis’), suggesting that a program for regeneration exists alongside programs for death (apoptosis) and division (mitosis). In two Reviews describing how emerging concepts...
Journal Articles
Journal Articles
Journal Articles
Dis Model Mech (2017) 10 (1): 63–76.
Published: 1 January 2017
.... ( 2015 ). High-resolution tissue Doppler imaging of the zebrafish heart during its regeneration . Zebrafish   12 , 48 - 57 . 10.1089/zeb.2014.1026 Kalam , K. , Otahal , P. and Marwick , T. H. ( 2014 ). Prognostic implications of global LV dysfunction: a systematic review...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2016) 9 (10): 1125–1137.
Published: 1 October 2016
... ). Astrocyte scar formation aids central nervous system axon regeneration . Nature   532 , 195 - 200 . 10.1038/nature17623 Angeli , C. A. , Edgerton , V. R. , Gerasimenko , Y. P. and Harkema , S. J. ( 2014 ). Altering spinal cord excitability enables voluntary movements after...
Journal Articles
Dis Model Mech (2016) 9 (5): 487–499.
Published: 1 May 2016
...Hongjie Li; Heinrich Jasper ABSTRACT The gastrointestinal tract of complex metazoans is highly compartmentalized. It is lined by a series of specialized epithelia that are regenerated by specific populations of stem cells. To maintain tissue homeostasis, the proliferative activity of stem...
Journal Articles
In collection:
Neurodegeneration
Dis Model Mech (2016) 9 (3): 235–244.
Published: 1 March 2016
..., we highlight the physiological and molecular parallels between fly and human organs that validate the use of Drosophila to study the molecular pathogenesis underlying human diseases. Drosophila Human disease models Nervous system Neurodegeneration Regeneration Heart Liver Oenocyte...
Includes: Supplementary data
Journal Articles
Journal Articles
Dis Model Mech (2015) 8 (6): 553–564.
Published: 1 June 2015
... in the nervous system, but the dynamic interactions between peripheral neurons and Schwann cells during injury and regeneration remain incompletely characterized. Here, we combine laser microsurgery, genetic analysis, high-resolution intravital imaging and lattice light-sheet microscopy to study the interaction...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2014) 7 (7): 769–776.
Published: 1 July 2014
...Wolfram Goessling; Trista E. North Regenerative medicine has the promise to alleviate morbidity and mortality caused by organ dysfunction, longstanding injury and trauma. Although regenerative approaches for a few diseases have been highly successful, some organs either do not regenerate well...
Journal Articles