... the consequences of its absence. We report the generation, molecular validation and phenotypic characterization of a novel rat model with a truncating Magel2 mutation modeling variants associated with Schaaf-Yang syndrome-causing mutations. Within the hypothalamus, a brain region in which human MAGEL2...

... of the importance of peri-interventional monitoring to verify a successful experimental performance in order to ensure a disease model that is as homogeneous as possible. tMCAO Rat model Stroke animal model Peri-interventional monitoring Experimental quality assurance Deutsche...

... with in-frame mutations in Dmd has been established. As a result, the effect of in-frame mutations on the dystrophin expression profile and disease progression of BMD remains unclear. In this study, we established a novel rat model carrying in-frame Dmd gene mutations (IF rats) and evaluated the pathology. We...

.... , Mangano , F. T. and Goto , J. ( 2019 ). Characterization of a novel rat model of X-linked hydrocephalus by CRISPR-mediated mutation in L1cam . J. Neurosurg. [Epub ahead of print] 10.3171/2018.10.JNS181015 Fryns , J. P. , Spaepen , A. , Cassiman , J. J. and van den Berghe...

... License ( http://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Summary: Using rat models of familial and inflammation-induced colon cancer, this study demonstrates...