1-12 of 12
Keywords: Rat
Close
Sort by
Journal Articles
Journal Articles
Journal Articles
Dis Model Mech (2018) 11 (3): dmm032839.
Published: 12 March 2018
... maintained. The Mouse Genome Database (MGD, http://www.informatics.jax.org), Rat Genome Database (RGD, http://rgd.mcw.edu) and Disease Ontology (DO, http://www.disease-ontology.org) projects are collaborating to augment DO, aligning and incorporating disease terms used by MGD and RGD, and improving DO...
Journal Articles
Journal Articles
Dis Model Mech (2016) 9 (12): 1419–1433.
Published: 1 December 2016
...Linda J. Mullins; Bryan R. Conway; Robert I. Menzies; Laura Denby; John J. Mullins ABSTRACT The rat has classically been the species of choice for pharmacological studies and disease modeling, providing a source of high-quality physiological data on cardiovascular and renal pathophysiology over...
Journal Articles
Dis Model Mech (2016) 9 (10): 1097–1110.
Published: 1 October 2016
... into a more comprehensive study design, called systems genetics, which aims to unravel the complex biological networks and pathways involved in disease, and in turn map their genetic control points. The first fully integrated systems genetics study was carried out in rats, and the results, which revealed...
Journal Articles
Dis Model Mech (2016) 9 (10): 1203–1210.
Published: 1 October 2016
..., the fundamental understanding of the biology of HEV replication is limited and there are few therapeutic options. The development of such therapies is partially hindered by the lack of a robust and convenient animal model. We propose the infection of athymic nude rats with the rat HEV strain LA-B350...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2016) 9 (10): 1125–1137.
Published: 1 October 2016
...Jacob Kjell; Lars Olson ABSTRACT A long-standing goal of spinal cord injury research is to develop effective spinal cord repair strategies for the clinic. Rat models of spinal cord injury provide an important mammalian model in which to evaluate treatment strategies and to understand...
Journal Articles
Dis Model Mech (2016) 9 (10): 1139–1146.
Published: 1 October 2016
... individuals to a variety of early-onset cancers. Development of appropriate translational animal models that carry mutations in Tp53 and recapitulate human disease are important for drug discovery, biomarker development and disease modeling. Current Tp53 mouse and rat models have significant phenotypic...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2016) 9 (10): 1079–1087.
Published: 1 October 2016
... compared to rats. This shift was primarily instigated by the availability of a much larger genetic toolbox for mice, particularly embryonic-stem-cell-based targeting technology for gene disruption. With the recent emergence of tools for altering the rat genome, notably genome-editing technologies...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2016) 9 (10): 1069–1072.
Published: 1 October 2016
...Tim Aitman; Paraminder Dhillon; Aron M. Geurts ABSTRACT Future prospects continue to be strong for research using the rat as a model organism. New technology has enabled the proliferation of many new transgenic and knockout rat strains, the genomes of more than 40 rat strains have been sequenced...
Journal Articles