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1-12 of 12
Keywords: Rat
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Journal Articles
In collection:
Moving Heart Failure to Heart Success
Xiao-yu Jiang, Fei-fei Guan, Jia-xin Ma, Wei Dong, Xiao-long Qi, Xu Zhang, Wei Chen, Shan Gao, Xiang Gao, Shuo Pan, Ji-zheng Wang, Yuan-wu Ma, Lian-feng Zhang, Dan Lu
Journal:
Disease Models & Mechanisms
Dis Model Mech (2023) 16 (5): dmm049444.
Published: 18 August 2022
... to find new and effective intervention targets. Here, myocardium-specific Trim44 knockout rats were generated using CRISPR-Cas9 technology. Cardiac phenotypic observations revealed that Trim44 knockout affected cardiac morphology at baseline. Rats with Trim44 deficiency exhibited resistance to cardiac...
Includes: Supplementary data
Journal Articles
In collection:
Moving Heart Failure to Heart Success
,
Neuromuscular Disease
,
Rat as a Disease Model
Petra Lujza Szabó, Janine Ebner, Xaver Koenig, Ouafa Hamza, Simon Watzinger, Sandra Trojanek, Dietmar Abraham, Hannes Todt, Helmut Kubista, Klaus Schicker, Séverine Remy, Ignacio Anegon, Attila Kiss, Bruno K. Podesser, Karlheinz Hilber
Journal:
Disease Models & Mechanisms
Dis Model Mech (2021) 14 (2): dmm047704.
Published: 22 February 2021
.... This has increased the need for basic research efforts into animal models for DMD. Here, we characterized in detail the cardiovascular abnormalities of Dmd mdx rats, with the aim of determining the suitability of this recently established dystrophin-deficient small animal as a model for DMD. Various...
Includes: Supplementary data
Journal Articles
Susan M. Bello, Mary Shimoyama, Elvira Mitraka, Stanley J. F. Laulederkind, Cynthia L. Smith, Janan T. Eppig, Lynn M. Schriml
Journal:
Disease Models & Mechanisms
Dis Model Mech (2018) 11 (3): dmm032839.
Published: 12 March 2018
... maintained. The Mouse Genome Database (MGD, http://www.informatics.jax.org), Rat Genome Database (RGD, http://rgd.mcw.edu) and Disease Ontology (DO, http://www.disease-ontology.org) projects are collaborating to augment DO, aligning and incorporating disease terms used by MGD and RGD, and improving DO...
Journal Articles
Philip M. Coan, Oliver Hummel, Ana Garcia Diaz, Marjorie Barrier, Neza Alfazema, Penny J. Norsworthy, Michal Pravenec, Enrico Petretto, Norbert Hübner, Timothy J. Aitman
Journal:
Disease Models & Mechanisms
Dis Model Mech (2017) 10 (3): 297–306.
Published: 1 March 2017
...Philip M. Coan; Oliver Hummel; Ana Garcia Diaz; Marjorie Barrier; Neza Alfazema; Penny J. Norsworthy; Michal Pravenec; Enrico Petretto; Norbert Hübner; Timothy J. Aitman ABSTRACT We previously mapped hypertension-related insulin resistance quantitative trait loci (QTLs) to rat chromosomes 4, 12...
Includes: Supplementary data
Journal Articles
In collection:
Rat as a Disease Model
Journal:
Disease Models & Mechanisms
Dis Model Mech (2016) 9 (12): 1419–1433.
Published: 1 December 2016
...Linda J. Mullins; Bryan R. Conway; Robert I. Menzies; Laura Denby; John J. Mullins ABSTRACT The rat has classically been the species of choice for pharmacological studies and disease modeling, providing a source of high-quality physiological data on cardiovascular and renal pathophysiology over...
Journal Articles
In collection:
Rat as a Disease Model
Journal:
Disease Models & Mechanisms
Dis Model Mech (2016) 9 (10): 1097–1110.
Published: 1 October 2016
... into a more comprehensive study design, called systems genetics, which aims to unravel the complex biological networks and pathways involved in disease, and in turn map their genetic control points. The first fully integrated systems genetics study was carried out in rats, and the results, which revealed...
Journal Articles
In collection:
Rat as a Disease Model
Journal:
Disease Models & Mechanisms
Dis Model Mech (2016) 9 (10): 1069–1072.
Published: 1 October 2016
...Tim Aitman; Paraminder Dhillon; Aron M. Geurts ABSTRACT Future prospects continue to be strong for research using the rat as a model organism. New technology has enabled the proliferation of many new transgenic and knockout rat strains, the genomes of more than 40 rat strains have been sequenced...
Journal Articles
In collection:
Rat as a Disease Model
Journal:
Disease Models & Mechanisms
Dis Model Mech (2016) 9 (10): 1203–1210.
Published: 1 October 2016
..., the fundamental understanding of the biology of HEV replication is limited and there are few therapeutic options. The development of such therapies is partially hindered by the lack of a robust and convenient animal model. We propose the infection of athymic nude rats with the rat HEV strain LA-B350...
Includes: Supplementary data
Journal Articles
In collection:
Rat as a Disease Model
Journal:
Disease Models & Mechanisms
Dis Model Mech (2016) 9 (10): 1125–1137.
Published: 1 October 2016
...Jacob Kjell; Lars Olson ABSTRACT A long-standing goal of spinal cord injury research is to develop effective spinal cord repair strategies for the clinic. Rat models of spinal cord injury provide an important mammalian model in which to evaluate treatment strategies and to understand...
Journal Articles
Journal:
Disease Models & Mechanisms
Dis Model Mech (2016) 9 (10): 1079–1087.
Published: 1 October 2016
... compared to rats. This shift was primarily instigated by the availability of a much larger genetic toolbox for mice, particularly embryonic-stem-cell-based targeting technology for gene disruption. With the recent emergence of tools for altering the rat genome, notably genome-editing technologies...
Includes: Supplementary data
Journal Articles
Sarah A. Hansen, Marcia L. Hart, Susheel Busi, Taybor Parker, Angela Goerndt, Kevin Jones, James M. Amos-Landgraf, Elizabeth C. Bryda
Journal:
Disease Models & Mechanisms
Dis Model Mech (2016) 9 (10): 1139–1146.
Published: 1 October 2016
... individuals to a variety of early-onset cancers. Development of appropriate translational animal models that carry mutations in Tp53 and recapitulate human disease are important for drug discovery, biomarker development and disease modeling. Current Tp53 mouse and rat models have significant phenotypic...
Includes: Supplementary data
Journal Articles
Ana Isabel Garcia Diaz, Ben Moyon, Philip M. Coan, Neza Alfazema, Lara Venda, Kevin Woollard, Tim Aitman
Journal:
Disease Models & Mechanisms
Dis Model Mech (2016) 9 (4): 463–471.
Published: 1 April 2016
...Ana Isabel Garcia Diaz; Ben Moyon; Philip M. Coan; Neza Alfazema; Lara Venda; Kevin Woollard; Tim Aitman ABSTRACT The Wistar Kyoto (WKY) rat and the spontaneously hypertensive (SHR) rat inbred strains are well-established models for human crescentic glomerulonephritis (CRGN) and metabolic syndrome...
Includes: Supplementary data