...-term cure. Mouse models of salivary gland injury are routinely used in regenerative research. However, there is no clear consensus on the radiation regime required to cause injury. Here, we analysed three regimes of γ-irradiation of the submandibular salivary gland. Transcriptional analysis...

...Hitoshi Uchida; Matthew H. Ingalls; Eri O. Maruyama; Carl J. Johnston; Eric Hernady; Roberta C. Faustoferri; Catherine E. Ovitt ABSTRACT Many patients treated for head and neck cancers experience salivary gland hypofunction due to radiation damage. Understanding the mechanisms of cellular damage...

... in embryonic neurons, sensitizing them to radiation-induced cell death. These findings suggest that diseased cells with mutations in splicing factors are vulnerable to radiotherapy. Splicing Radiation Apoptosis Zebrafish R-loops Neurons American Cancer Society 10.13039/100000048 RSG...

...Azza A. Al-Mahrouki; Sara Iradji; William Tyler Tran; Gregory J. Czarnota Tumor radiation resistance poses a major obstacle in achieving an optimal outcome in radiation therapy. In the current study, we characterize a novel therapeutic approach that combines ultrasound-driven microbubbles...