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Keywords: RNA sequencing
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Journal Articles
Dis Model Mech dmm.049086.
Published: 08 September 2021
...-mediated renin overexpression, UNx-Renin) DKD using RNA sequencing (RNAseq). Compared to normoglycemic db/m mice, db/db UNx and db/db UNx-Renin mice showed marked changes in kidney cortical and glomerular gene expression profiles. UNx-Renin mice displayed more marked perturbations in gene components...
Journal Articles
Dis Model Mech (2018) 11 (9): dmm033530.
Published: 25 September 2018
... imaging and measured gene regulation by RNA sequencing and reverse transcription quantitative PCR analyses. Our results show that ER stress potentiated intracellular lipid accumulation by 5-fold in hiPSC-Hep in the absence of apoptosis. Transcriptome pathway analysis identified ER stress pathways...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2017) 10 (11): 1353–1369.
Published: 01 November 2017
..., their relevance as models of the molecular aspects of the disease is yet to be decided. Herein, we conducted unbiased RNA sequencing to profile the transcriptomes of fibroblast cell lines derived from 18 FRDA patients and 17 unaffected control individuals. Bioinformatic analyses revealed significantly upregulated...
Includes: Supplementary data