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Keywords: RAS signaling
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Journal Articles
In collection:
The RAS Pathway
Journal:
Disease Models & Mechanisms
Dis Model Mech (2022) 15 (8): dmm049422.
Published: 29 August 2022
... have been useful in identifying cellular and molecular mechanisms that regulate NF1-dependent behaviors, translating these discoveries into effective treatments has proven difficult. Clinical trials measuring cognitive outcomes in patients with NF1 have mainly targeted RAS signaling but, unfortunately...
Journal Articles
In collection:
The RAS Pathway
Xi Jin, Victor Ng, Meiling Zhao, Lu Liu, Tomoyasu Higashimoto, Zheng Hong Lee, Jooho Chung, Victor Chen, Gina Ney, Malathi Kandarpa, Moshe Talpaz, Qing Li
Journal:
Disease Models & Mechanisms
Dis Model Mech (2022) 15 (5): dmm049088.
Published: 6 May 2022
... at the SOCS2 locus. Finally, restoration of SOCS2 in RAS mutant AML cells mitigated leukemic growth. Thus, we discovered a novel signaling feedback loop whereby hyperactive Ras signaling activates Jak2/Stat5 via suppression of Socs2. * Author for correspondence ( [email protected] ) Handling Editor...
Includes: Supplementary data
Journal Articles
Felix Oppel, Dong H. Ki, Mark W. Zimmerman, Kenneth N. Ross, Ting Tao, Hui Shi, Shuning He, Jon C. Aster, A. Thomas Look
Journal:
Disease Models & Mechanisms
Dis Model Mech (2020) 13 (8): dmm042341.
Published: 27 August 2020
... as diverse other tumors, is accelerated by loss of the suz12 tumor suppressor, accompanied by global reduction in H3K27me3 marks and increased Ras-Mapk signaling. MPNST Leukemia SUZ12 p53 NF1 RAS signaling Alterations in genes encoding epigenetic regulators of gene expression have become...
Includes: Supplementary data