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Keywords: RAS signaling
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Journal Articles
In collection:
The RAS Pathway
Dis Model Mech (2022) 15 (8): dmm049422.
Published: 29 August 2022
... have been useful in identifying cellular and molecular mechanisms that regulate NF1-dependent behaviors, translating these discoveries into effective treatments has proven difficult. Clinical trials measuring cognitive outcomes in patients with NF1 have mainly targeted RAS signaling but, unfortunately...
Journal Articles
In collection:
The RAS Pathway
Dis Model Mech (2022) 15 (5): dmm049088.
Published: 6 May 2022
... at the SOCS2 locus. Finally, restoration of SOCS2 in RAS mutant AML cells mitigated leukemic growth. Thus, we discovered a novel signaling feedback loop whereby hyperactive Ras signaling activates Jak2/Stat5 via suppression of Socs2. * Author for correspondence ( [email protected] ) Handling Editor...
Includes: Supplementary data
Journal Articles