... attributed. Summary: The mechanistic examination of the human condition combined with in vitro and in vivo modeling studies demonstrate how RAS pathway dysregulation in RASopathies affects mammalian skeletal muscle development. Cardio-facio-cutaneous syndrome Costello syndrome Myopathy...

... and enhance healthspan. MEK inhibitor RAS pathway Ageing Globally, people are living longer. In developed nations, most people are expected to live well into their 70s and beyond ( www.who.int/data/gho/data/themes/mortality-and-global-health-estimates/ghe-life-expectancy-and-healthy-life...

.... In this Editorial, we reflect on this Special Issue and how its articles fit into the broader context of this exciting field. Fig. 1. The RAS pathway beyond the tip of the iceberg. Over the past four decades, researchers have encountered successes and hurdles in effective targeting of aberrant RAS...

... this difficulty, research has focused on the molecular dissection of the RAS pathway to gain a more-precise mechanistic understanding of its regulation, with the hope to identify new pharmacological approaches. Here, we review the current knowledge on the (dys)regulation of the RAS pathway, using melanoma...