...John E. La Marca; Robert W. Ely; Sarah T. Diepstraten; Peter Burke; Gemma L. Kelly; Patrick O. Humbert; Helena E. Richardson ABSTRACT Elevated Ras signalling is highly prevalent in human cancer; however, targeting Ras-driven cancers with Ras pathway inhibitors often leads to undesirable side...

.... With the cloning of the NF1 gene and the recognition that the encoded protein, neurofibromin, largely functions as a negative regulator of RAS activity, attention has mainly focused on RAS and canonical RAS effector pathway signaling relevant to disease pathogenesis and treatment. However, as neurofibromin...

...Katie E. Hebron; Edjay Ralph Hernandez; Marielle E. Yohe ABSTRACT The RASopathies are a group of disorders caused by a germline mutation in one of the genes encoding a component of the RAS/MAPK pathway. These disorders, including neurofibromatosis type 1, Noonan syndrome, cardiofaciocutaneous...

... defects. The etiology underlying the pathogenesis of cleft palate has yet to be fully elucidated. Dissociation of the medial edge epithelium (MEE) at the contacting region of palatal shelves and subsequent migration or apoptosis of MEE cells is required for proper MEE removal. Ras-responsive element...

...Alexandra Redding; Andrew E. Aplin; Elda Grabocka ABSTRACT Cellular stress is known to function in synergistic cooperation with oncogenic mutations during tumorigenesis to drive cancer progression. Oncogenic RAS is a strong inducer of a variety of pro-tumorigenic cellular stresses, and also...

...Yogesh Goyal; Thomas J. Levario; Henry H. Mattingly; Susan Holmes; Stanislav Y. Shvartsman; Hang Lu ABSTRACT The Ras pathway patterns the poles of the Drosophila embryo by downregulating the levels and activity of a DNA-binding transcriptional repressor Capicua (Cic). We demonstrate...

... originate from similar events, with Yap1 as a driving force in tumour development. Glioma YAP RAS Zebrafish Heterotopia Disorders of brain growth are known to cause a wide range of physiological and pathological symptoms such as intractable epilepsy, intellectual disability, autism...