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Keywords: R-loops
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Journal Articles
Dis Model Mech (2018) 11 (2): dmm031583.
Published: 26 February 2018
... accumulation of R-loops, which are non-canonical nucleic acid structures that promote genomic instability. Dampening R-loop formation by conditional induction of ribonuclease H1 in sf3b1 mutants reduced neuronal DNA damage and apoptosis. These findings show that splicing factor dysfunction leads to R-loop...
Includes: Supplementary data