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Keywords: Purkinje cells
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Journal Articles
Dis Model Mech (2024) 17 (6): dmm050379.
Published: 12 June 2024
...Luis E. Salazar Leon; Amanda M. Brown; Heet Kaku; Roy V. Sillitoe ABSTRACT Purkinje cell dysfunction disrupts movement and causes disorders such as ataxia. Recent evidence suggests that Purkinje cell dysfunction may also alter sleep regulation. Here, we used an ataxic mouse model generated...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2022) 15 (8): dmm049514.
Published: 5 August 2022
..., was accompanied by non-progressive abnormal activity of their upstream synaptic inputs, the Purkinje cells. In vitro recordings indicated that alterations in intrinsic Purkinje cell pacemaking and in their synaptic inputs contributed to abnormal Purkinje cell activity. These findings implicate abnormal cerebellar...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2021) 14 (6): dmm044834.
Published: 24 June 2021
... connection between SCA and Ronin (Thap11), a polyglutamine-containing transcriptional regulator encoded in a region of human chromosome 16q22.1 that has been genetically linked to SCA type 4. We report that transgenic expression of Ronin in mouse cerebellar Purkinje cells leads to detrimental loss...
Includes: Supplementary data
Journal Articles