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Keywords: Pulmonary artery stenosis
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Journal Articles
In collection:
The RAS Pathway
Rifdat Aoidi, Nicolas Houde, Kim Landry-Truchon, Michael Holter, Kevin Jacquet, Louis Charron, Suguna Rani Krishnaswami, Benjamin D. Yu, Katherine A. Rauen, Nicolas Bisson, Jason Newbern, Jean Charron
Journal:
Disease Models & Mechanisms
Dis Model Mech (2018) 11 (3): dmm031278.
Published: 13 March 2018
..., Mek1 Y130C mutants showed increased ERK (MAPK) protein activation in response to growth factors, supporting a role for MEK1 Y130C in hyperactivation of the RAS/MAPK pathway, leading to CFC. Mek1 Y130C mutant mice exhibited pulmonary artery stenosis, cranial dysmorphia and neurological anomalies...
Includes: Supplementary data