... that these pathways do modulate protein aggregation. Taken together, our results showed that the modulation of deregulated pathways influences protein aggregation in HD, and has implications for progression and prognosis. This article has an associated First Person interview with the first author of the paper...

... of degenerating MNs in ALS, i.e. protein aggregation and mitochondrial dysfunction. Moreover, different gene mutations have different effects on ALS cellular mechanisms. TARDBP and FUS mutations imbalance mitochondrial dynamism toward increased fusion, whereas sALS and SOD1 mutations mainly affect fission...

...-related neurodegenerative disorders, especially Alzheimer's disease. Circadian biology Clearance Protein aggregation Proteostasis Sleep dysfunction The circadian clock is a complex biological machine that allows organisms, from fruit flies to humans, to predict and prepare...